Biggin PC - Search Results

1

Molecular basis for pH sensing in the KDEL trafficking receptor.

Wu Z, Smith K, Gerondopoulos A, Sobajima T, Parker JL, Barr FA, Newstead S, Biggin PC. Wu Z, et al. Among authors: biggin pc. Structure. 2024 Apr 12:S0969-2126(24)00095-9. doi: 10.1016/j.str.2024.03.013. Online ahead of print. Structure. 2024. PMID: 38626766 Free article.

2

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment.

Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S. Bharambe N, et al. Among authors: biggin pc. Nat Commun. 2024 Apr 5;15(1):2967. doi: 10.1038/s41467-024-47370-w. Nat Commun. 2024. PMID: 38580666 Free PMC article.

3

Selective Potentiation of the (α4)₃(β2)₂ Nicotinic Acetylcholine Receptor Response by NS9283 Analogues.

Appiani R, Viscarra F, Biggin PC, Bermudez I, Giraudo A, Pallavicini M, Bolchi C. Appiani R, et al. Among authors: biggin pc. ACS Chem Neurosci. 2024 Apr 3;15(7):1501-1514. doi: 10.1021/acschemneuro.3c00797. Epub 2024 Mar 21. ACS Chem Neurosci. 2024. PMID: 38511291 Free article.

4

Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface.

Larsen AH, Perozzo AM, Biggin PC, Bowie D, Kastrup JS. Larsen AH, et al. Among authors: biggin pc. J Biol Chem. 2024 Mar;300(3):105717. doi: 10.1016/j.jbc.2024.105717. Epub 2024 Feb 2. J Biol Chem. 2024. PMID: 38311178 Free PMC article.

5

Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.

Bay Y, Venskutonytė R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS. Bay Y, et al. Among authors: biggin pc. FEBS J. 2024 Apr;291(7):1506-1529. doi: 10.1111/febs.17046. Epub 2024 Feb 23. FEBS J. 2024. PMID: 38145505

6

Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.

Thomas AM, Serafini M, Grant EK, Coombs EAJ, Bluck JP, Schiedel M, McDonough MA, Reynolds JK, Lee B, Platt M, Sharlandjieva V, Biggin PC, Duarte F, Milne TA, Bush JT, Conway SJ. Thomas AM, et al. Among authors: biggin pc. ACS Chem Biol. 2023 Nov 17;18(11):2405-2417. doi: 10.1021/acschembio.3c00437. Epub 2023 Oct 24. ACS Chem Biol. 2023. PMID: 37874862 Free PMC article.

7

Computed Protein-Protein Enthalpy Signatures as a Tool for Identifying Conformation Sampling Problems.

Çınaroğlu SS, Biggin PC. Çınaroğlu SS, et al. Among authors: biggin pc. J Chem Inf Model. 2023 Oct 9;63(19):6095-6108. doi: 10.1021/acs.jcim.3c01041. Epub 2023 Sep 27. J Chem Inf Model. 2023. PMID: 37759363 Free PMC article.

8

Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator.

Viscarra F, Chrestia JF, Sanchez Y, Pérez EG, Biggin PC, Bouzat C, Bermudez I, López JJ. Viscarra F, et al. Among authors: biggin pc. ACS Chem Neurosci. 2023 Aug 16;14(16):2876-2887. doi: 10.1021/acschemneuro.3c00225. Epub 2023 Aug 3. ACS Chem Neurosci. 2023. PMID: 37535446

9

Correction: Limitations of non-polarizable force fields in describing anion binding poses in non-polar synthetic hosts.

Seiferth D, Tucker SJ, Biggin PC. Seiferth D, et al. Among authors: biggin pc. Phys Chem Chem Phys. 2023 Jul 26;25(29):20145. doi: 10.1039/d3cp90150e. Phys Chem Chem Phys. 2023. PMID: 37455541 Free PMC article.

10

Limitations of non-polarizable force fields in describing anion binding poses in non-polar synthetic hosts.

Seiferth D, Tucker SJ, Biggin PC. Seiferth D, et al. Among authors: biggin pc. Phys Chem Chem Phys. 2023 Jul 5;25(26):17596-17608. doi: 10.1039/d3cp00479a. Phys Chem Chem Phys. 2023. PMID: 37365974 Free PMC article.

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