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Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.
Bay Y, Venskutonytė R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS. Bay Y, et al. Among authors: kristensen as. FEBS J. 2024 Apr;291(7):1506-1529. doi: 10.1111/febs.17046. Epub 2024 Feb 23. FEBS J. 2024. PMID: 38145505
Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.
Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. Naur P, et al. Among authors: kristensen as. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14116-21. doi: 10.1073/pnas.0703718104. Epub 2007 Aug 21. Proc Natl Acad Sci U S A. 2007. PMID: 17715062 Free PMC article.
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS. Clausen RP, et al. Among authors: kristensen as. J Med Chem. 2009 Aug 13;52(15):4911-22. doi: 10.1021/jm900565c. J Med Chem. 2009. PMID: 19588945
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.
Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K. Bach A, et al. Among authors: kristensen as. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. doi: 10.1073/pnas.1113761109. Epub 2012 Feb 17. Proc Natl Acad Sci U S A. 2012. PMID: 22343531 Free PMC article.
83 results