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Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone.
Levinstein MR, De Oliveira PA, Casajuana-Martin N, Quiroz C, Budinich RC, Rais R, Rea W, Ventriglia EN, Llopart N, Casadó-Anguera V, Moreno E, Walther D, Glatfelter GC, Weinshenker D, Zarate CA Jr, Casadó V, Baumann MH, Pardo L, Ferré S, Michaelides M. Levinstein MR, et al. Among authors: rais r. Mol Psychiatry. 2023 Dec 25. doi: 10.1038/s41380-023-02353-z. Online ahead of print. Mol Psychiatry. 2023. PMID: 38145984
Essential role of P-glycoprotein in the mechanism of action of oliceridine.
Ventriglia E, Rizzo A, Gomez JL, Friedman J, Lam S, Solís O, Rais R, Bonaventura J, Michaelides M. Ventriglia E, et al. Among authors: rais r. Neuropsychopharmacology. 2023 Apr;48(5):831-842. doi: 10.1038/s41386-022-01507-x. Epub 2022 Nov 25. Neuropsychopharmacology. 2023. PMID: 36434081 Free PMC article.
Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone.
Michaelides M, Levinstein M, De Oliveira P, Casajuana-Martin N, Quiroz C, Budinich R, Rais R, Rea W, Ventriglia E, Llopart N, Casadó-Anguera V, Moreno E, Walther D, Glatfelter G, Weinshenker D, Zarate C, Casado V, Baumann M, Pardo L, Ferre S. Michaelides M, et al. Among authors: rais r. Res Sq [Preprint]. 2023 Mar 23:rs.3.rs-2644719. doi: 10.21203/rs.3.rs-2644719/v1. Res Sq. 2023. PMID: 36993715 Free PMC article. Updated. Preprint.
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility.
Ramos A, Ishizuka K, Hayashida A, Namkung H, Hayes LN, Srivastava R, Zhang M, Kariya T, Elkins N, Palen T, Carloni E, Tsujimura T, Calva C, Ikemoto S, Rais R, Slusher BS, Niwa M, Saito A, Saitoh T, Takimoto E, Sawa A. Ramos A, et al. Among authors: rais r. Mol Psychiatry. 2024 Apr 13. doi: 10.1038/s41380-024-02553-1. Online ahead of print. Mol Psychiatry. 2024. PMID: 38615102
A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH. Galaj E, et al. Among authors: rais r. Neuropsychopharmacology. 2022 Dec;47(13):2309-2318. doi: 10.1038/s41386-022-01379-1. Epub 2022 Jul 25. Neuropsychopharmacology. 2022. PMID: 35879349 Free PMC article.
Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
Lemberg KM, Ali ES, Krecmerova M, Aguilar JMH, Alt J, Peters DE, Zhao L, Wu Y, Nuha N, Asara JM, Staedtke V, Pratilas CA, Majer P, Rais R, Ben-Sahra I, Slusher BS. Lemberg KM, et al. Among authors: rais r. Mol Cancer Ther. 2023 Dec 1;22(12):1390-1403. doi: 10.1158/1535-7163.MCT-23-0258. Mol Cancer Ther. 2023. PMID: 37616542 Free PMC article.
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.
Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH. Kumar V, et al. Among authors: rais r. J Med Chem. 2016 Aug 25;59(16):7634-50. doi: 10.1021/acs.jmedchem.6b00860. Epub 2016 Aug 10. J Med Chem. 2016. PMID: 27508895 Free PMC article.
169 results