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A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation.
Abe Y, Kofman ER, Ouyang Z, Cruz-Becerra G, Spann NJ, Seidman JS, Troutman TD, Stender JD, Taylor H, Fan W, Link VM, Shen Z, Sakai J, Downes M, Evans RM, Kadonaga JT, Rosenfeld MG, Glass CK. Abe Y, et al. Among authors: sakai j. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2316104121. doi: 10.1073/pnas.2316104121. Epub 2024 Jan 2. Proc Natl Acad Sci U S A. 2024. PMID: 38165941 Free PMC article.
Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.
Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J. Matsumura Y, et al. Among authors: sakai j. Nat Commun. 2021 Dec 2;12(1):7045. doi: 10.1038/s41467-021-27321-5. Nat Commun. 2021. PMID: 34857762 Free PMC article.
COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J. Okamura M, et al. Among authors: sakai j. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5819-24. doi: 10.1073/pnas.0901676106. Epub 2009 Mar 23. Proc Natl Acad Sci U S A. 2009. PMID: 19307559 Free PMC article.
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. Tanaka T, et al. Among authors: sakai j. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9. doi: 10.1073/pnas.0306981100. Epub 2003 Dec 15. Proc Natl Acad Sci U S A. 2003. PMID: 14676330 Free PMC article.
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J. Abe Y, et al. Among authors: sakai j. Nat Commun. 2015 May 7;6:7052. doi: 10.1038/ncomms8052. Nat Commun. 2015. PMID: 25948511 Free PMC article.
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion.
Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT. Fujino T, et al. Among authors: sakai j. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34. doi: 10.1073/pnas.0133792100. Epub 2002 Dec 30. Proc Natl Acad Sci U S A. 2003. PMID: 12509515 Free PMC article.
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J, Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y, Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y, Matsumura Y, Sakai J. Takahashi H, et al. Among authors: sakai j. Nat Commun. 2022 Sep 29;13(1):5715. doi: 10.1038/s41467-022-33363-0. Nat Commun. 2022. PMID: 36175407 Free PMC article.
602 results