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A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits.
bioRxiv [Preprint]. 2023 Dec 13:2023.12.12.571316. doi: 10.1101/2023.12.12.571316.
bioRxiv. 2023.
PMID: 38168200
Free PMC article.
Preprint.
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries.
An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S.
An U, et al. Among authors: pazokitoroudi a.
Nat Genet. 2023 Dec;55(12):2269-2276. doi: 10.1038/s41588-023-01558-w. Epub 2023 Nov 20.
Nat Genet. 2023.
PMID: 37985819
Free PMC article.
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A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis.
Fu B, Pazokitoroudi A, Xue A, Anand A, Anand P, Zaitlen N, Sankararaman S.
Fu B, et al. Among authors: pazokitoroudi a.
bioRxiv [Preprint]. 2023 Sep 12:2023.09.10.557084. doi: 10.1101/2023.09.10.557084.
bioRxiv. 2023.
PMID: 37745394
Free PMC article.
Preprint.
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Fast kernel-based association testing of non-linear genetic effects for biobank-scale data.
Fu B, Pazokitoroudi A, Sudarshan M, Liu Z, Subramanian L, Sankararaman S.
Fu B, et al. Among authors: pazokitoroudi a.
Nat Commun. 2023 Aug 15;14(1):4936. doi: 10.1038/s41467-023-40346-2.
Nat Commun. 2023.
PMID: 37582955
Free PMC article.
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The lingering effects of Neanderthal introgression on human complex traits.
Wei X, Robles CR, Pazokitoroudi A, Ganna A, Gusev A, Durvasula A, Gazal S, Loh PR, Reich D, Sankararaman S.
Wei X, et al. Among authors: pazokitoroudi a.
Elife. 2023 Mar 20;12:e80757. doi: 10.7554/eLife.80757.
Elife. 2023.
PMID: 36939312
Free PMC article.
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Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions.
Findley AS, Monziani A, Richards AL, Rhodes K, Ward MC, Kalita CA, Alazizi A, Pazokitoroudi A, Sankararaman S, Wen X, Lanfear DE, Pique-Regi R, Gilad Y, Luca F.
Findley AS, et al. Among authors: pazokitoroudi a.
Elife. 2021 May 14;10:e67077. doi: 10.7554/eLife.67077.
Elife. 2021.
PMID: 33988505
Free PMC article.
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Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data.
Pazokitoroudi A, Chiu AM, Burch KS, Pasaniuc B, Sankararaman S.
Pazokitoroudi A, et al.
Am J Hum Genet. 2021 May 6;108(5):799-808. doi: 10.1016/j.ajhg.2021.03.018. Epub 2021 Apr 2.
Am J Hum Genet. 2021.
PMID: 33811807
Free PMC article.
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Efficient variance components analysis across millions of genomes.
Pazokitoroudi A, Wu Y, Burch KS, Hou K, Zhou A, Pasaniuc B, Sankararaman S.
Pazokitoroudi A, et al.
Nat Commun. 2020 Aug 11;11(1):4020. doi: 10.1038/s41467-020-17576-9.
Nat Commun. 2020.
PMID: 32782262
Free PMC article.
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