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IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development.
Goh W, Sudholz H, Foroutan M, Scheer S, Pfefferle A, Delconte RB, Meng X, Shen Z, Hennessey R, Kong IY, Schuster IS, Andoniou CE, Davis MJ, Hediyeh-Zadeh S, Souza-Fonseca-Guimaraes F, Parish IA, Beavis P, Thiele D, Chopin M, Degli-Esposti MA, Cursons J, Kallies A, Rautela J, Nutt SL, Huntington ND. Goh W, et al. Among authors: beavis p. Nat Immunol. 2024 Feb;25(2):240-255. doi: 10.1038/s41590-023-01718-4. Epub 2024 Jan 5. Nat Immunol. 2024. PMID: 38182668
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
House IG, Derrick EB, Sek K, Chen AXY, Li J, Lai J, Todd KL, Munoz I, Michie J, Chan CW, Huang YK, Chan JD, Petley EV, Tong J, Nguyen D, Engel S, Savas P, Hogg SJ, Vervoort SJ, Kearney CJ, Burr ML, Lam EYN, Gilan O, Bedoui S, Johnstone RW, Dawson MA, Loi S, Darcy PK, Beavis PA. House IG, et al. Among authors: beavis pa. Cell Rep. 2024 Feb 27;43(2):113793. doi: 10.1016/j.celrep.2024.113793. Epub 2024 Feb 5. Cell Rep. 2024. PMID: 38324452 Free article. No abstract available.
The role of exhaustion in CAR T cell therapy.
Delgoffe GM, Xu C, Mackall CL, Green MR, Gottschalk S, Speiser DE, Zehn D, Beavis PA. Delgoffe GM, et al. Cancer Cell. 2021 Jul 12;39(7):885-888. doi: 10.1016/j.ccell.2021.06.012. Cancer Cell. 2021. PMID: 34256903 Free article.
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy.
Beavis PA, Henderson MA, Giuffrida L, Mills JK, Sek K, Cross RS, Davenport AJ, John LB, Mardiana S, Slaney CY, Johnstone RW, Trapani JA, Stagg J, Loi S, Kats L, Gyorki D, Kershaw MH, Darcy PK. Beavis PA, et al. J Clin Invest. 2017 Mar 1;127(3):929-941. doi: 10.1172/JCI89455. Epub 2017 Feb 6. J Clin Invest. 2017. PMID: 28165340 Free PMC article.
Correction: RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.
Loi S, Dushyanthen S, Beavis PA, Salgado R, Denkert C, Savas P, Combs S, Rimm DL, Giltnane JM, Estrada MV, Sánchez V, Sanders ME, Cook RS, Pilkinton MA, Mallal SA, Wang K, Miller VA, Stephens PJ, Yelensky R, Doimi FD, Gómez H, Ryzhov SV, Darcy PK, Arteaga CL, Balko JM. Loi S, et al. Among authors: beavis pa. Clin Cancer Res. 2019 Feb 15;25(4):1437. doi: 10.1158/1078-0432.CCR-18-4264. Clin Cancer Res. 2019. PMID: 30770496 No abstract available.
Sex-specific adipose tissue imprinting of regulatory T cells.
Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, Zhan Y, Torres SV, Liene S, Collins N, Cao E, Sidwell T, Li C, Spallanzani RG, Liao Y, Beavis PA, Gebhardt T, Trevaskis N, Nutt SL, Zajac JD, Davey RA, Febbraio MA, Mathis D, Shi W, Kallies A. Vasanthakumar A, et al. Nature. 2020 Mar;579(7800):581-585. doi: 10.1038/s41586-020-2040-3. Epub 2020 Feb 26. Nature. 2020. PMID: 32103173 Free PMC article.
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity.
Lai J, Mardiana S, House IG, Sek K, Henderson MA, Giuffrida L, Chen AXY, Todd KL, Petley EV, Chan JD, Carrington EM, Lew AM, Solomon BJ, Trapani JA, Kedzierska K, Evrard M, Vervoort SJ, Waithman J, Darcy PK, Beavis PA. Lai J, et al. Nat Immunol. 2020 Aug;21(8):914-926. doi: 10.1038/s41590-020-0676-7. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424363
87 results