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AAV-Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness.
Qi J, Tan F, Zhang L, Lu L, Zhang S, Zhai Y, Lu Y, Qian X, Dong W, Zhou Y, Zhang Z, Yang X, Jiang L, Yu C, Liu J, Chen T, Wu L, Tan C, Sun S, Song H, Shu Y, Xu L, Gao X, Li H, Chai R. Qi J, et al. Among authors: tan c, tan f. Adv Sci (Weinh). 2024 Mar;11(11):e2306788. doi: 10.1002/advs.202306788. Epub 2024 Jan 8. Adv Sci (Weinh). 2024. PMID: 38189623 Free PMC article.
AAV-ie enables safe and efficient gene transfer to inner ear cells.
Tan F, Chu C, Qi J, Li W, You D, Li K, Chen X, Zhao W, Cheng C, Liu X, Qiao Y, Su B, He S, Zhong C, Li H, Chai R, Zhong G. Tan F, et al. Nat Commun. 2019 Aug 19;10(1):3733. doi: 10.1038/s41467-019-11687-8. Nat Commun. 2019. PMID: 31427575 Free PMC article.
AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration.
Tao Y, Liu X, Yang L, Chu C, Tan F, Yu Z, Ke J, Li X, Zheng X, Zhao X, Qi J, Lin CP, Chai R, Zhong G, Wu H. Tao Y, et al. Among authors: tan f. Signal Transduct Target Ther. 2022 Apr 22;7(1):109. doi: 10.1038/s41392-022-00938-8. Signal Transduct Target Ther. 2022. PMID: 35449181 Free PMC article.
Critical role of TPRN rings in the stereocilia for hearing.
Qi J, Tan F, Zhang L, Zhou Y, Zhang Z, Sun Q, Li N, Fang Y, Chen X, Wu Y, Zhong G, Chai R. Qi J, et al. Among authors: tan f. Mol Ther. 2024 Jan 3;32(1):204-217. doi: 10.1016/j.ymthe.2023.11.011. Epub 2023 Nov 11. Mol Ther. 2024. PMID: 37952086
AAV-mediated Gpm6b expression supports hair cell reprogramming.
Sun Q, Zhang L, Chen T, Li N, Tan F, Gu X, Zhou Y, Zhang Z, Lu Y, Lu J, Qian X, Guan B, Qi J, Ye F, Chai R. Sun Q, et al. Among authors: tan f. Cell Prolif. 2024 Feb 24:e13620. doi: 10.1111/cpr.13620. Online ahead of print. Cell Prolif. 2024. PMID: 38400824
2,273 results