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822 results

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Human fetal brain self-organizes into long-term expanding organoids.
Hendriks D, Pagliaro A, Andreatta F, Ma Z, van Giessen J, Massalini S, López-Iglesias C, van Son GJF, DeMartino J, Damen JMA, Zoutendijk I, Staliarova N, Bredenoord AL, Holstege FCP, Peters PJ, Margaritis T, Chuva de Sousa Lopes S, Wu W, Clevers H, Artegiani B. Hendriks D, et al. Among authors: clevers h. Cell. 2024 Feb 1;187(3):712-732.e38. doi: 10.1016/j.cell.2023.12.012. Epub 2024 Jan 8. Cell. 2024. PMID: 38194967 Free article.
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, Tans S, Lopez-Iglesias C, Peters PJ, Wu W, Kotlarz D, Klein C, Margaritis T, Holstege F, Clevers H. He GW, et al. Among authors: clevers h. Cell Stem Cell. 2022 Dec 1;29(12):1718-1720. doi: 10.1016/j.stem.2022.11.001. Cell Stem Cell. 2022. PMID: 36459971 Free PMC article. No abstract available.
Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.
Mertens S, Huismans MA, Verissimo CS, Ponsioen B, Overmeer R, Proost N, van Tellingen O, van de Ven M, Begthel H, Boj SF, Clevers H, Roodhart JML, Bos JL, Snippert HJG. Mertens S, et al. Among authors: clevers h. Cell Rep. 2023 Apr 25;42(4):112324. doi: 10.1016/j.celrep.2023.112324. Epub 2023 Mar 30. Cell Rep. 2023. PMID: 37000626 Free article.
Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification.
Millen R, De Kort WWB, Koomen M, van Son GJF, Gobits R, Penning de Vries B, Begthel H, Zandvliet M, Doornaert P, Raaijmakers CPJ, Geurts MH, Elias SG, van Es RJJ, de Bree R, Devriese LA, Willems SM, Kranenburg O, Driehuis E, Clevers H. Millen R, et al. Among authors: clevers h. Med. 2023 May 12;4(5):290-310.e12. doi: 10.1016/j.medj.2023.04.003. Med. 2023. PMID: 37178682 Free article.
Nanoblades allow high-level genome editing in murine and human organoids.
Tiroille V, Krug A, Bokobza E, Kahi M, Bulcaen M, Ensinck MM, Geurts MH, Hendriks D, Vermeulen F, Larbret F, Gutierrez-Guerrero A, Chen Y, Van Zundert I, Rocha S, Rios AC, Medaer L, Gijsbers R, Mangeot PE, Clevers H, Carlon MS, Bost F, Verhoeyen E. Tiroille V, et al. Among authors: clevers h. Mol Ther Nucleic Acids. 2023 Jun 8;33:57-74. doi: 10.1016/j.omtn.2023.06.004. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37435135 Free PMC article.
Human conjunctiva organoids to study ocular surface homeostasis and disease.
Bannier-Hélaouët M, Korving J, Ma Z, Begthel H, Giladi A, Lamers MM, van de Wetering WJ, Yawata N, Yawata M, LaPointe VLS, Dickman MM, Kalmann R, Imhoff SM, van Es JH, López-Iglesias C, Peters PJ, Haagmans BL, Wu W, Clevers H. Bannier-Hélaouët M, et al. Among authors: clevers h. Cell Stem Cell. 2024 Feb 1;31(2):227-243.e12. doi: 10.1016/j.stem.2023.12.008. Epub 2024 Jan 11. Cell Stem Cell. 2024. PMID: 38215738 Free article.
Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids.
Leon-Icaza SA, Bagayoko S, Vergé R, Iakobachvili N, Ferrand C, Aydogan T, Bernard C, Sanchez Dafun A, Murris-Espin M, Mazières J, Bordignon PJ, Mazères S, Bernes-Lasserre P, Ramé V, Lagarde JM, Marcoux J, Bousquet MP, Chalut C, Guilhot C, Clevers H, Peters PJ, Molle V, Lugo-Villarino G, Cam K, Berry L, Meunier E, Cougoule C. Leon-Icaza SA, et al. Among authors: clevers h. PLoS Pathog. 2023 Aug 24;19(8):e1011559. doi: 10.1371/journal.ppat.1011559. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37619220 Free PMC article.
822 results