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Page 1
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
Ritzefeld M, Zhang L, Xiao Z, Andrei SA, Boyd O, Masumoto N, Rodgers UR, Artelsmair M, Sefer L, Hayes A, Gavriil ES, Raynaud FI, Burke R, Blagg J, Rzepa HS, Siebold C, Magee AI, Lanyon-Hogg T, Tate EW. Ritzefeld M, et al. Among authors: lanyon hogg t. J Med Chem. 2024 Jan 25;67(2):1061-1078. doi: 10.1021/acs.jmedchem.3c01363. Epub 2024 Jan 10. J Med Chem. 2024. PMID: 38198226 Free PMC article.
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Jamshidiha M, Lanyon-Hogg T, Sutherell CL, Craven GB, Tersa M, De Vita E, Brustur D, Pérez-Dorado I, Hassan S, Petracca R, Morgan RM, Sanz-Hernández M, Norman JC, Armstrong A, Mann DJ, Cota E, Tate EW. Jamshidiha M, et al. Among authors: lanyon hogg t. RSC Med Chem. 2021 Dec 16;13(2):150-155. doi: 10.1039/d1md00225b. eCollection 2022 Feb 23. RSC Med Chem. 2021. PMID: 35308027 Free PMC article.
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE, Andrei SA, Ansell TB, Carrique L, Kumar P, Sefer L, Schwab RA, Byrne EFX, Pardon E, Steyaert J, Magee AI, Lanyon-Hogg T, Sansom MSP, Tate EW, Siebold C. Coupland CE, et al. Among authors: lanyon hogg t. Mol Cell. 2021 Dec 16;81(24):5025-5038.e10. doi: 10.1016/j.molcel.2021.11.018. Epub 2021 Dec 9. Mol Cell. 2021. PMID: 34890564 Free PMC article.
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.
Kallemeijn WW, Lanyon-Hogg T, Panyain N, Goya Grocin A, Ciepla P, Morales-Sanfrutos J, Tate EW. Kallemeijn WW, et al. Among authors: lanyon hogg t. Nat Protoc. 2021 Nov;16(11):5083-5122. doi: 10.1038/s41596-021-00601-6. Epub 2021 Oct 27. Nat Protoc. 2021. PMID: 34707257 Review.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Angew Chem Weinheim Bergstr Ger. 2021 Jun 7;133(24):13654-13659. doi: 10.1002/ange.202014457. Epub 2021 May 14. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 38504937 Free PMC article.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547. doi: 10.1002/anie.202014457. Epub 2021 May 14. Angew Chem Int Ed Engl. 2021. PMID: 33768725 Free PMC article.
Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity".
Panyain N, Godinat A, Lanyon-Hogg T, Lachiondo-Ortega S, Will EJ, Soudy C, Mondal M, Mason K, Elkhalifa S, Smith LM, Harrigan JA, Tate EW. Panyain N, et al. Among authors: lanyon hogg t. J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19. J Am Chem Soc. 2020. PMID: 32812749 Free PMC article. No abstract available.
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
Panyain N, Godinat A, Lanyon-Hogg T, Lachiondo-Ortega S, Will EJ, Soudy C, Mondal M, Mason K, Elkhalifa S, Smith LM, Harrigan JA, Tate EW. Panyain N, et al. Among authors: lanyon hogg t. J Am Chem Soc. 2020 Jul 15;142(28):12020-12026. doi: 10.1021/jacs.0c04527. Epub 2020 Jul 1. J Am Chem Soc. 2020. PMID: 32579346 Free PMC article.
30 results