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Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
J Med Chem. 2024 Jan 25;67(2):1061-1078. doi: 10.1021/acs.jmedchem.3c01363. Epub 2024 Jan 10.
J Med Chem. 2024.
PMID: 38198226
Free PMC article.
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE, Andrei SA, Ansell TB, Carrique L, Kumar P, Sefer L, Schwab RA, Byrne EFX, Pardon E, Steyaert J, Magee AI, Lanyon-Hogg T, Sansom MSP, Tate EW, Siebold C.
Coupland CE, et al. Among authors: sefer l.
Mol Cell. 2021 Dec 16;81(24):5025-5038.e10. doi: 10.1016/j.molcel.2021.11.018. Epub 2021 Dec 9.
Mol Cell. 2021.
PMID: 34890564
Free PMC article.
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Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW.
Lanyon-Hogg T, et al. Among authors: sefer l.
Angew Chem Weinheim Bergstr Ger. 2021 Jun 7;133(24):13654-13659. doi: 10.1002/ange.202014457. Epub 2021 May 14.
Angew Chem Weinheim Bergstr Ger. 2021.
PMID: 38504937
Free PMC article.
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Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW.
Lanyon-Hogg T, et al. Among authors: sefer l.
Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547. doi: 10.1002/anie.202014457. Epub 2021 May 14.
Angew Chem Int Ed Engl. 2021.
PMID: 33768725
Free PMC article.
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NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA.
Sewell L, Stylianou F, Xu Y, Taylor J, Sefer L, Matthews S.
Sewell L, et al. Among authors: sefer l.
Sci Rep. 2020 May 12;10(1):7896. doi: 10.1038/s41598-020-64135-9.
Sci Rep. 2020.
PMID: 32398666
Free PMC article.
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Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes.
Lanyon-Hogg T, Ritzefeld M, Sefer L, Bickel JK, Rudolf AF, Panyain N, Bineva-Todd G, Ocasio CA, O'Reilly N, Siebold C, Magee AI, Tate EW.
Lanyon-Hogg T, et al. Among authors: sefer l.
Chem Sci. 2019 Jul 1;10(39):8995-9000. doi: 10.1039/c9sc01785b. eCollection 2019 Oct 21.
Chem Sci. 2019.
PMID: 31762980
Free PMC article.
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Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
Taylor JD, Hawthorne WJ, Lo J, Dear A, Jain N, Meisl G, Andreasen M, Fletcher C, Koch M, Darvill N, Scull N, Escalera-Maurer A, Sefer L, Wenman R, Lambert S, Jean J, Xu Y, Turner B, Kazarian SG, Chapman MR, Bubeck D, de Simone A, Knowles TP, Matthews SJ.
Taylor JD, et al. Among authors: sefer l.
Sci Rep. 2016 Apr 21;6:24656. doi: 10.1038/srep24656.
Sci Rep. 2016.
PMID: 27098162
Free PMC article.
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The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.
Evans ML, Chorell E, Taylor JD, Åden J, Götheson A, Li F, Koch M, Sefer L, Matthews SJ, Wittung-Stafshede P, Almqvist F, Chapman MR.
Evans ML, et al. Among authors: sefer l.
Mol Cell. 2015 Feb 5;57(3):445-55. doi: 10.1016/j.molcel.2014.12.025. Epub 2015 Jan 22.
Mol Cell. 2015.
PMID: 25620560
Free PMC article.
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