Tate EW - Search Results

1

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Ritzefeld M, Zhang L, Xiao Z, Andrei SA, Boyd O, Masumoto N, Rodgers UR, Artelsmair M, Sefer L, Hayes A, Gavriil ES, Raynaud FI, Burke R, Blagg J, Rzepa HS, Siebold C, Magee AI, Lanyon-Hogg T, Tate EW. Ritzefeld M, et al. Among authors: tate ew. J Med Chem. 2024 Jan 25;67(2):1061-1078. doi: 10.1021/acs.jmedchem.3c01363. Epub 2024 Jan 10. J Med Chem. 2024. PMID: 38198226 Free PMC article.

2

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.

Thongyoo P, Bonomelli C, Leatherbarrow RJ, Tate EW. Thongyoo P, et al. Among authors: tate ew. J Med Chem. 2009 Oct 22;52(20):6197-200. doi: 10.1021/jm901233u. J Med Chem. 2009. PMID: 19772295

3

Bioorthogonal chemical tagging of protein cholesterylation in living cells.

Heal WP, Jovanovic B, Bessin S, Wright MH, Magee AI, Tate EW. Heal WP, et al. Among authors: tate ew. Chem Commun (Camb). 2011 Apr 14;47(14):4081-3. doi: 10.1039/c0cc04710d. Epub 2011 Jan 11. Chem Commun (Camb). 2011. PMID: 21221452 Free article.

4

Novel inhibitors of surface layer processing in Clostridium difficile.

Tam Dang TH, Fagan RP, Fairweather NF, Tate EW. Tam Dang TH, et al. Among authors: tate ew. Bioorg Med Chem. 2012 Jan 15;20(2):614-21. doi: 10.1016/j.bmc.2011.06.042. Epub 2011 Jun 21. Bioorg Med Chem. 2012. PMID: 21752656 Free article.

5

Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ. Goncalves V, et al. Among authors: tate ew. J Med Chem. 2012 Apr 12;55(7):3578-82. doi: 10.1021/jm300040p. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22439843 Free PMC article.

6

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Yu Z, et al. Among authors: tate ew. J Med Chem. 2012 Oct 25;55(20):8879-90. doi: 10.1021/jm301160h. Epub 2012 Oct 15. J Med Chem. 2012. PMID: 23035716 Free PMC article.

7

Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.

Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Rackham MD, et al. Among authors: tate ew. J Med Chem. 2013 Jan 10;56(1):371-5. doi: 10.1021/jm301474t. Epub 2012 Dec 17. J Med Chem. 2013. PMID: 23170970 Free PMC article.

8

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

Konitsiotis AD, Chang SC, Jovanović B, Ciepla P, Masumoto N, Palmer CP, Tate EW, Couchman JR, Magee AI. Konitsiotis AD, et al. Among authors: tate ew. PLoS One. 2014 Mar 7;9(3):e89899. doi: 10.1371/journal.pone.0089899. eCollection 2014. PLoS One. 2014. PMID: 24608521 Free PMC article.

9

Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).

Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Rackham MD, et al. Among authors: tate ew. J Med Chem. 2014 Mar 27;57(6):2773-88. doi: 10.1021/jm500066b. Epub 2014 Mar 18. J Med Chem. 2014. PMID: 24641010 Free PMC article.

10

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Hutton JA, et al. Among authors: tate ew. J Med Chem. 2014 Oct 23;57(20):8664-70. doi: 10.1021/jm5011397. Epub 2014 Oct 1. J Med Chem. 2014. PMID: 25238611 Free PMC article.

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