Arruda AP - Search Results

1

Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis.

Chang CF, Gunawan AL, Liparulo I, Zushin PH, Vitangcol K, Timblin GA, Saijo K, Wang B, Parlakgül G, Arruda AP, Stahl A. Chang CF, et al. Among authors: arruda ap. EMBO J. 2024 Jan;43(2):168-195. doi: 10.1038/s44318-023-00008-x. Epub 2024 Jan 11. EMBO J. 2024. PMID: 38212382 Free PMC article.

2

Integration of ER protein quality control mechanisms defines β cell function and ER architecture.

Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L. Shrestha N, et al. Among authors: arruda ap. J Clin Invest. 2023 Jan 3;133(1):e163584. doi: 10.1172/JCI163584. J Clin Invest. 2023. PMID: 36346671 Free PMC article.

3

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS. Goncalves RLS, et al. Among authors: arruda ap. bioRxiv [Preprint]. 2023 Feb 22:2023.02.21.528863. doi: 10.1101/2023.02.21.528863. bioRxiv. 2023. PMID: 36865319 Free PMC article. Preprint.

4

Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets.

Bairos JA, Njoku U, Zafar M, Akl MG, Li L, Parlakgul G, Arruda AP, Widenmaier SB. Bairos JA, et al. Among authors: arruda ap. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May 16;1869(6):159512. doi: 10.1016/j.bbalip.2024.159512. Online ahead of print. Biochim Biophys Acta Mol Cell Biol Lipids. 2024. PMID: 38761895 Free article.

5

Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.

Parlakgül G, Pang S, Artico LL, Min N, Cagampan E, Villa R, Goncalves RLS, Lee GY, Xu CS, Hotamışlıgil GS, Arruda AP. Parlakgül G, et al. Among authors: arruda ap. Nat Commun. 2024 May 10;15(1):3982. doi: 10.1038/s41467-024-48272-7. Nat Commun. 2024. PMID: 38729945 Free PMC article.

6

Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.

Arruda AP, Parlakgül G. Arruda AP, et al. Cold Spring Harb Perspect Biol. 2023 Feb 1;15(2):a041261. doi: 10.1101/cshperspect.a041261. Cold Spring Harb Perspect Biol. 2023. PMID: 35940911 Review.

7

Regulation of liver subcellular architecture controls metabolic homeostasis.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Parlakgül G, et al. Among authors: arruda ap. Nature. 2022 Mar;603(7902):736-742. doi: 10.1038/s41586-022-04488-5. Epub 2022 Mar 9. Nature. 2022. PMID: 35264794 Free PMC article.

8

Aberrant Ca²⁺ signaling by IP₃Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Guney E, et al. Among authors: arruda ap. Sci Signal. 2021 Dec 14;14(713):eabf2059. doi: 10.1126/scisignal.abf2059. Epub 2021 Dec 14. Sci Signal. 2021. PMID: 34905386 Free PMC article.

9

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Tirosh A, et al. Among authors: arruda ap. Cell Metab. 2021 Aug 3;33(8):1716. doi: 10.1016/j.cmet.2021.07.005. Cell Metab. 2021. PMID: 34348100 Free PMC article. No abstract available.

10

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Tirosh A, et al. Among authors: arruda ap. Cell Metab. 2021 Feb 2;33(2):319-333.e6. doi: 10.1016/j.cmet.2020.11.009. Epub 2020 Dec 18. Cell Metab. 2021. PMID: 33340456 Free PMC article.

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