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An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318003121. doi: 10.1073/pnas.2318003121. Epub 2024 May 1.
Proc Natl Acad Sci U S A. 2024.
PMID: 38691588
Free PMC article.
Instability of the HLA-E peptidome of HIV presents a major barrier to therapeutic targeting.
Wallace Z, Heunis T, Paterson RL, Suckling RJ, Grant T, Dembek M, Donoso J, Brener J, Long J, Bunjobpol W, Gibbs-Howe D, Kay DP, Leneghan DB, Godinho LF, Walker A, Singh PK, Knox A, Leonard S, Dorrell L.
Wallace Z, et al. Among authors: gibbs howe d.
Mol Ther. 2024 Mar 6;32(3):678-688. doi: 10.1016/j.ymthe.2024.01.010. Epub 2024 Jan 12.
Mol Ther. 2024.
PMID: 38219014
Free article.
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Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Barber C, De Souza VA, Paterson RL, Martin-Urdiroz M, Mulakkal NC, Srikannathasan V, Connolly M, Phillips G, Foong-Leong T, Pengelly R, Karuppiah V, Grant T, Dembek M, Verma A, Gibbs-Howe D, Blicher TH, Knox A, Robinson RA, Cole DK, Leonard S.
Barber C, et al. Among authors: gibbs howe d.
Eur J Immunol. 2022 Apr;52(4):618-632. doi: 10.1002/eji.202149745. Epub 2022 Feb 13.
Eur J Immunol. 2022.
PMID: 35108401
Free PMC article.
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