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An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
Paterson RL, La Manna MP, Arena De Souza V, Walker A, Gibbs-Howe D, Kulkarni R, Fergusson JR, Mulakkal NC, Monteiro M, Bunjobpol W, Dembek M, Martin-Urdiroz M, Grant T, Barber C, Garay-Baquero DJ, Tezera LB, Lowne D, Britton-Rivet C, Pengelly R, Chepisiuk N, Singh PK, Woon AP, Powlesland AS, McCully ML, Caccamo N, Salio M, Badami GD, Dorrell L, Knox A, Robinson R, Elkington P, Dieli F, Lepore M, Leonard S, Godinho LF. Paterson RL, et al. Among authors: gibbs howe d. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318003121. doi: 10.1073/pnas.2318003121. Epub 2024 May 1. Proc Natl Acad Sci U S A. 2024. PMID: 38691588 Free PMC article.
Instability of the HLA-E peptidome of HIV presents a major barrier to therapeutic targeting.
Wallace Z, Heunis T, Paterson RL, Suckling RJ, Grant T, Dembek M, Donoso J, Brener J, Long J, Bunjobpol W, Gibbs-Howe D, Kay DP, Leneghan DB, Godinho LF, Walker A, Singh PK, Knox A, Leonard S, Dorrell L. Wallace Z, et al. Among authors: gibbs howe d. Mol Ther. 2024 Mar 6;32(3):678-688. doi: 10.1016/j.ymthe.2024.01.010. Epub 2024 Jan 12. Mol Ther. 2024. PMID: 38219014 Free article.
Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Barber C, De Souza VA, Paterson RL, Martin-Urdiroz M, Mulakkal NC, Srikannathasan V, Connolly M, Phillips G, Foong-Leong T, Pengelly R, Karuppiah V, Grant T, Dembek M, Verma A, Gibbs-Howe D, Blicher TH, Knox A, Robinson RA, Cole DK, Leonard S. Barber C, et al. Among authors: gibbs howe d. Eur J Immunol. 2022 Apr;52(4):618-632. doi: 10.1002/eji.202149745. Epub 2022 Feb 13. Eur J Immunol. 2022. PMID: 35108401 Free PMC article.