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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity.
Holling GA, Chavel CA, Sharda AP, Lieberman MM, James CM, Lightman SM, Tong JH, Qiao G, Emmons TR, Giridharan T, Hou S, Intlekofer AM, Higashi RM, Fan TWM, Lane AN, Eng KH, Segal BH, Repasky EA, Lee KP, Olejniczak SH. Holling GA, et al. Among authors: eng kh. Cell Mol Immunol. 2024 Mar;21(3):260-274. doi: 10.1038/s41423-024-01124-2. Epub 2024 Jan 18. Cell Mol Immunol. 2024. PMID: 38233562 Free PMC article.
Stratification of Patients with Renal Cell Carcinoma by the Abundance of Sarcomatoid Features Reveals Differences in Survival and the Underlying Pathobiology.
Salgia NJ, Aubrecht WM, Wang L, Ram B, Wasik BJ, Khan A, Attwood K, Daza J, Long MD, Eng KH, Xu B, Muhitch JB, Kauffman EC. Salgia NJ, et al. Among authors: eng kh. Eur Urol Oncol. 2024 Mar 12:S2588-9311(24)00052-X. doi: 10.1016/j.euo.2024.02.007. Online ahead of print. Eur Urol Oncol. 2024. PMID: 38480032
Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers.
Omole EB, Aijaz I, Ellegate J Jr, Isenhart E, Desouki MM, Mastri M, Humphrey K, Dougherty EM, Rosario SR, Nastiuk KL, Ohm JE, Eng KH. Omole EB, et al. Among authors: eng kh. Cancers (Basel). 2022 Sep 28;14(19):4724. doi: 10.3390/cancers14194724. Cancers (Basel). 2022. PMID: 36230652 Free PMC article.
Mitigating the prevalence and function of myeloid-derived suppressor cells by redirecting myeloid differentiation using a novel immune modulator.
Oliver L, Alvarez R, Diaz R, Valdés A, Colligan SH, Nemeth MJ, Twum DYF, Fernández A, Fernández-Medina O, Carlson LM, Yu H, Eng KH, Hensen ML, Rábade-Chediak ML, Fernández LE, Lee KP, Perez L, Muhitch JB, Mesa C, Abrams SI. Oliver L, et al. Among authors: eng kh. J Immunother Cancer. 2022 Sep;10(9):e004710. doi: 10.1136/jitc-2022-004710. J Immunother Cancer. 2022. PMID: 36150744 Free PMC article. Clinical Trial.
VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients.
Khan ANH, Emmons TR, Magner WJ, Alqassim E, Singel KL, Ricciuti J, Eng KH, Odunsi K, Tomasi TB, Lee K, Abrams SI, Mesa C, Segal BH. Khan ANH, et al. Among authors: eng kh. Cancer Immunol Immunother. 2022 Oct;71(10):2355-2369. doi: 10.1007/s00262-022-03156-x. Epub 2022 Feb 15. Cancer Immunol Immunother. 2022. PMID: 35166871 Free PMC article.
Patient derived models of bladder cancer enrich the signal of the tumor cell transcriptome facilitating the analysis of the tumor cell compartment.
Mastri M, Ramakrishnan S, Shah SD, Karasik E, Gillard BM, Moser MT, Farmer BK, Azabdaftari G, Chatta GS, Woloszynska A, Eng KH, Foster BA, Huss WJ. Mastri M, et al. Among authors: eng kh. Am J Clin Exp Urol. 2021 Dec 15;9(6):416-434. eCollection 2021. Am J Clin Exp Urol. 2021. PMID: 34993263 Free PMC article.
88 results