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Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target.
Wazir S, Parviainen TAO, Pfannenstiel JJ, Duong MTH, Cluff D, Sowa ST, Galera-Prat A, Ferraris D, Maksimainen MM, Fehr AR, Heiskanen JP, Lehtiö L. Wazir S, et al. Among authors: lehtio l. bioRxiv [Preprint]. 2023 Dec 27:2023.08.28.555062. doi: 10.1101/2023.08.28.555062. bioRxiv. 2023. PMID: 38234730 Free PMC article. Updated. Preprint.
Structural basis for DNA break recognition by ARTD2/PARP2.
Obaji E, Haikarainen T, Lehtiö L. Obaji E, et al. Among authors: lehtio l. Nucleic Acids Res. 2018 Dec 14;46(22):12154-12165. doi: 10.1093/nar/gky927. Nucleic Acids Res. 2018. PMID: 30321391 Free PMC article.
Homogeneous screening assay for human tankyrase.
Narwal M, Fallarero A, Vuorela P, Lehtiö L. Narwal M, et al. Among authors: lehtio l. J Biomol Screen. 2012 Jun;17(5):593-604. doi: 10.1177/1087057112436558. Epub 2012 Feb 21. J Biomol Screen. 2012. PMID: 22357873
Zinc binding catalytic domain of human tankyrase 1.
Lehtiö L, Collins R, van den Berg S, Johansson A, Dahlgren LG, Hammarström M, Helleday T, Holmberg-Schiavone L, Karlberg T, Weigelt J. Lehtiö L, et al. J Mol Biol. 2008 May 23;379(1):136-45. doi: 10.1016/j.jmb.2008.03.058. Epub 2008 Apr 3. J Mol Biol. 2008. PMID: 18436240
Buried charged surface in proteins.
Kajander T, Kahn PC, Passila SH, Cohen DC, Lehtiö L, Adolfsen W, Warwicker J, Schell U, Goldman A. Kajander T, et al. Among authors: lehtio l. Structure. 2000 Nov 15;8(11):1203-14. doi: 10.1016/s0969-2126(00)00520-7. Structure. 2000. PMID: 11080642 Free article.
100 results