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Five dominant dimensions of brain aging are identified via deep learning: associations with clinical, lifestyle, and genetic measures.
Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga A, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Bryan NR, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Yang Z, et al. Among authors: morris jc. medRxiv [Preprint]. 2023 Dec 30:2023.12.29.23300642. doi: 10.1101/2023.12.29.23300642. medRxiv. 2023. PMID: 38234857 Free PMC article. Preprint.
Chronotype is Associated with Sleep Quality in Older Adults.
Sauers SC, Toedebusch CD, Richardson R, Spira AP, Morris JC, Holtzman DM, Lucey BP. Sauers SC, et al. Among authors: morris jc. medRxiv [Preprint]. 2023 Sep 6:2023.09.04.23294997. doi: 10.1101/2023.09.04.23294997. medRxiv. 2023. PMID: 37732218 Free PMC article. Updated. Preprint.
Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris J, Don A, Garfield A, Zarini S, Zemski Berry KA, Ryan A, Bergman BC, Brozinick JT, James DE, Burchfield JG. Diaz-Vegas A, et al. bioRxiv [Preprint]. 2023 Sep 19:2023.03.10.532020. doi: 10.1101/2023.03.10.532020. bioRxiv. 2023. PMID: 36945619 Free PMC article. Updated. Preprint.
Mapping Sleep's Oscillatory Events as a Biomarker of Alzheimer's Disease.
Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Pulver RL, et al. Among authors: morris jc. bioRxiv [Preprint]. 2023 Feb 16:2023.02.15.528725. doi: 10.1101/2023.02.15.528725. bioRxiv. 2023. PMID: 36824720 Free PMC article. Updated. Preprint.
Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.
Iaccarino L, Llibre-Guerra JJ, McDade E, Edwards L, Gordon B, Benzinger T, Hassenstab J, Kramer JH, Li Y, Miller BL, Miller Z, Morris JC, Mundada N, Perrin RJ, Rosen HJ, Soleimani-Meigooni D, Strom A, Tsoy E, Wang G, Xiong C, Allegri R, Chrem P, Vazquez S, Berman SB, Chhatwal J, Masters CL, Farlow MR, Jucker M, Levin J, Salloway S, Fox NC, Day GS, Gorno-Tempini ML, Boxer AL, La Joie R, Bateman R, Rabinovici GD. Iaccarino L, et al. Among authors: morris jc. Brain Commun. 2024 May 3;6(3):fcae159. doi: 10.1093/braincomms/fcae159. eCollection 2024. Brain Commun. 2024. PMID: 38784820 Free PMC article.
Correction: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.
Wohlwend M, Laurila PP, Goeminne LJE, de Lima TI, Daskalaki I, Li X, von Alvensleben G, Crisol B, Mangione R, Gallart-Ayala H, Lalou A, Burri O, Butler S, Morris JC, Turner N, Ivanisevic J, Auwerx J. Wohlwend M, et al. Among authors: morris jc. Elife. 2024 May 20;13:e99846. doi: 10.7554/eLife.99846. Elife. 2024. PMID: 38767943 Free PMC article.
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease.
Eteleeb AM, Novotny BC, Tarraga CS, Sohn C, Dhungel E, Brase L, Nallapu A, Buss J, Farias F, Bergmann K, Bradley J, Norton J, Gentsch J, Wang F, Davis AA, Morris JC, Karch CM, Perrin RJ, Benitez BA, Harari O. Eteleeb AM, et al. Among authors: morris jc. PLoS Biol. 2024 Apr 30;22(4):e3002607. doi: 10.1371/journal.pbio.3002607. eCollection 2024 Apr. PLoS Biol. 2024. PMID: 38687811 Free PMC article.
Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.
Wagemann O, Liu H, Wang G, Shi X, Bittner T, Scelsi MA, Farlow MR, Clifford DB, Supnet-Bell C, Santacruz AM, Aschenbrenner AJ, Hassenstab JJ, Benzinger TLS, Gordon BA, Coalier KA, Cruchaga C, Ibanez L, Perrin RJ, Xiong C, Li Y, Morris JC, Lah JJ, Berman SB, Roberson ED, van Dyck CH, Galasko D, Gauthier S, Hsiung GR, Brooks WS, Pariente J, Mummery CJ, Day GS, Ringman JM, Mendez PC, St George-Hyslop P, Fox NC, Suzuki K, Okhravi HR, Chhatwal J, Levin J, Jucker M, Sims JR, Holdridge KC, Proctor NK, Yaari R, Andersen SW, Mancini M, Llibre-Guerra J, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network–Trials Unit. Wagemann O, et al. Among authors: morris jc. JAMA Neurol. 2024 Apr 29:e240991. doi: 10.1001/jamaneurol.2024.0991. Online ahead of print. JAMA Neurol. 2024. PMID: 38683602 Free PMC article.
1,650 results