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Five dominant dimensions of brain aging are identified via deep learning: associations with clinical, lifestyle, and genetic measures.
Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga A, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Bryan NR, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Yang Z, et al. Among authors: wolk da. medRxiv [Preprint]. 2023 Dec 30:2023.12.29.23300642. doi: 10.1101/2023.12.29.23300642. medRxiv. 2023. PMID: 38234857 Free PMC article. Preprint.
Baseline levels and longitudinal rates of change in plasma Aβ42/40 among self-identified Black/African American and White individuals.
Xiong C, Schindler S, Luo J, Morris J, Bateman R, Holtzman D, Cruchaga C, Babulal G, Henson R, Benzinger T, Bui Q, Agboola F, Grant E, Emily G, Moulder K, Geldmacher D, Clay O, Roberson E, Murchison C, Wolk D, Shaw L. Xiong C, et al. Res Sq [Preprint]. 2024 Jan 8:rs.3.rs-3783571. doi: 10.21203/rs.3.rs-3783571/v1. Res Sq. 2024. PMID: 38260384 Free PMC article. Preprint.
Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups.
Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. Ma Y, et al. Among authors: wolk da. medRxiv [Preprint]. 2024 Feb 14:2024.02.12.24302533. doi: 10.1101/2024.02.12.24302533. medRxiv. 2024. PMID: 38405911 Free PMC article. Preprint.
α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies.
Kannarkat GT, Zack R, Skrinak RT, Morley JF, Davila-Rivera R, Arezoumandan S, Dorfmann K, Luk K, Wolk DA, Weintraub D, Tropea TF, Lee EB, Xie SX, Chandrasekaran G, Lee VM, Irwin D, Akhtar RS, Chen-Plotkin AS. Kannarkat GT, et al. Among authors: wolk da. bioRxiv [Preprint]. 2024 May 8:2024.05.07.593056. doi: 10.1101/2024.05.07.593056. bioRxiv. 2024. PMID: 38765963 Free PMC article. Preprint.
Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease.
Cousins KAQ, Phillips JS, Das SR, O'Brien K, Tropea TF, Chen-Plotkin A, Shaw LM, Nasrallah IM, Mechanic-Hamilton D, McMillan CT, Irwin DJ, Lee EB, Wolk DA. Cousins KAQ, et al. Among authors: wolk da. Alzheimers Dement. 2024 Apr 21. doi: 10.1002/alz.13777. Online ahead of print. Alzheimers Dement. 2024. PMID: 38644682
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study.
Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Christopher EA, DeTure M, Seeley WW, Lee EB, Frosch MP, Molina-Porcel L, Gefen T, Redding-Ochoa J, Ghetti B, Robinson AC, Kobylecki C, Rowe JB, Beach TG, Teich AF, Keith JL, Bodi I, Halliday GM, Gearing M, Arzberger T, Morris CM, White CL 3rd, Mechawar N, Boluda S, MacKenzie IR, McLean C, Cykowski MD, Wang SJ, Graff C, Nagra RM, Kovacs GG, Giaccone G, Neumann M, Ang LC, Carvalho A, Morris HR, Rademakers R, Hardy JA, Dickson DW, Rohrer JD, Ross OA; Pick's disease International Consortium. Valentino RR, et al. Lancet Neurol. 2024 May;23(5):487-499. doi: 10.1016/S1474-4422(24)00083-8. Lancet Neurol. 2024. PMID: 38631765 Free article.
325 results