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KS-WNK1 is Required for the Renal Response to Extreme Changes in Potassium Intake.
Bahena-Lopez JP, Vergara L, De la Peña V, Gutiérrez-Gallardo MA, López-Ibargüen P, García JA, Carbajal-Contreras H, Vázquez N, Rincón-Heredia R, Masso F, Bobadilla NA Sr, Castañeda-Bueno M, Ellison DH, Gamba G, Chávez-Canales M. Bahena-Lopez JP, et al. Among authors: chavez canales m. Am J Physiol Renal Physiol. 2024 Jan 25. doi: 10.1152/ajprenal.00235.2023. Online ahead of print. Am J Physiol Renal Physiol. 2024. PMID: 38269409
Insulin increases the functional activity of the renal NaCl cotransporter.
Chávez-Canales M, Arroyo JP, Ko B, Vázquez N, Bautista R, Castañeda-Bueno M, Bobadilla NA, Hoover RS, Gamba G. Chávez-Canales M, et al. J Hypertens. 2013 Feb;31(2):303-11. doi: 10.1097/HJH.0b013e32835bbb83. J Hypertens. 2013. PMID: 23303355 Free PMC article.
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J. Chávez-Canales M, et al. Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11. Hypertension. 2014. PMID: 25113964 Free PMC article.
The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.
Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, González-Rodríguez X, Vázquez N, Rodríguez-Gama A, Argaiz ER, Melo Z, Plata C, Ellison DH, García-Valdés J, Hadchouel J, Gamba G. Bazúa-Valenti S, et al. J Am Soc Nephrol. 2015 Aug;26(8):1781-6. doi: 10.1681/ASN.2014050470. Epub 2014 Dec 26. J Am Soc Nephrol. 2015. PMID: 25542968 Free PMC article.
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.
Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G. Mercado A, et al. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C54-66. doi: 10.1152/ajpcell.00193.2015. Epub 2016 May 11. Am J Physiol Cell Physiol. 2016. PMID: 27170636 Free PMC article.
Inactivation of SPAK kinase reduces body weight gain in mice fed a high-fat diet by improving energy expenditure and insulin sensitivity.
Torre-Villalvazo I, Cervantes-Pérez LG, Noriega LG, Jiménez JV, Uribe N, Chávez-Canales M, Tovar-Palacio C, Marfil-Garza BA, Torres N, Bobadilla NA, Tovar AR, Gamba G. Torre-Villalvazo I, et al. Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E53-E65. doi: 10.1152/ajpendo.00108.2017. Epub 2017 Oct 24. Am J Physiol Endocrinol Metab. 2018. PMID: 29066461 Free article.
Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.
Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama A, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D, Gamba G. Argaiz ER, et al. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F734-F745. doi: 10.1152/ajprenal.00145.2018. Epub 2018 May 30. Am J Physiol Renal Physiol. 2018. PMID: 29846116 Free PMC article.
Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X. Louis-Dit-Picard H, et al. J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171. J Clin Invest. 2020. PMID: 32790646 Free PMC article.
23 results