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Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME. Seddighi S, et al. Among authors: ward me. Sci Transl Med. 2024 Feb 14;16(734):eadg7162. doi: 10.1126/scitranslmed.adg7162. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38277467
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.
Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Zhang YJ, et al. Among authors: ward me. Science. 2019 Feb 15;363(6428):eaav2606. doi: 10.1126/science.aav2606. Science. 2019. PMID: 30765536 Free PMC article.
Bioengineered optogenetic model of human neuromuscular junction.
Vila OF, Chavez M, Ma SP, Yeager K, Zholudeva LV, Colón-Mercado JM, Qu Y, Nash TR, Lai C, Feliciano CM, Carter M, Kamm RD, Judge LM, Conklin BR, Ward ME, McDevitt TC, Vunjak-Novakovic G. Vila OF, et al. Among authors: ward me. Biomaterials. 2021 Sep;276:121033. doi: 10.1016/j.biomaterials.2021.121033. Epub 2021 Jul 30. Biomaterials. 2021. PMID: 34403849 Free PMC article.
Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons.
Chua JP, Bedi K, Paulsen MT, Ljungman M, Tank EMH, Kim ES, McBride JP, Colón-Mercado JM, Ward ME, Weisman LS, Barmada SJ. Chua JP, et al. Among authors: ward me. Curr Biol. 2022 Jun 20;32(12):2581-2595.e6. doi: 10.1016/j.cub.2022.04.053. Epub 2022 May 16. Curr Biol. 2022. PMID: 35580604 Free PMC article.
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M. Dräger NM, et al. Among authors: ward me. Nat Neurosci. 2022 Sep;25(9):1149-1162. doi: 10.1038/s41593-022-01131-4. Epub 2022 Aug 11. Nat Neurosci. 2022. PMID: 35953545 Free PMC article.
A cellular taxonomy of the adult human spinal cord.
Yadav A, Matson KJE, Li L, Hua I, Petrescu J, Kang K, Alkaslasi MR, Lee DI, Hasan S, Galuta A, Dedek A, Ameri S, Parnell J, Alshardan MM, Qumqumji FA, Alhamad SM, Wang AP, Poulen G, Lonjon N, Vachiery-Lahaye F, Gaur P, Nalls MA, Qi YA, Maric D, Ward ME, Hildebrand ME, Mery PF, Bourinet E, Bauchet L, Tsai EC, Phatnani H, Le Pichon CE, Menon V, Levine AJ. Yadav A, et al. Among authors: ward me. Neuron. 2023 Feb 1;111(3):328-344.e7. doi: 10.1016/j.neuron.2023.01.007. Neuron. 2023. PMID: 36731429 Free PMC article.
The era of cryptic exons: implications for ALS-FTD.
Mehta PR, Brown AL, Ward ME, Fratta P. Mehta PR, et al. Among authors: ward me. Mol Neurodegener. 2023 Mar 15;18(1):16. doi: 10.1186/s13024-023-00608-5. Mol Neurodegener. 2023. PMID: 36922834 Free PMC article. Review.
Application of Aligned-UMAP to longitudinal biomedical studies.
Dadu A, Satone VK, Kaur R, Koretsky MJ, Iwaki H, Qi YA, Ramos DM, Avants B, Hesterman J, Gunn R, Cookson MR, Ward ME, Singleton AB, Campbell RH, Nalls MA, Faghri F. Dadu A, et al. Among authors: ward me. Patterns (N Y). 2023 May 8;4(6):100741. doi: 10.1016/j.patter.2023.100741. eCollection 2023 Jun 9. Patterns (N Y). 2023. PMID: 37409055 Free PMC article.
Cognitive determinants of decisional capacity in neurodegenerative disorders.
Portley M, Sherer C, Wu T, Farren J, Danielian LE, Scholz SW, Traynor BJ, Ward ME, Haselhuhn T, Snyder A, Kwan JY. Portley M, et al. Among authors: ward me. Ann Clin Transl Neurol. 2023 Oct;10(10):1816-1823. doi: 10.1002/acn3.51871. Epub 2023 Aug 6. Ann Clin Transl Neurol. 2023. PMID: 37545108 Free PMC article.
329 results