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A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD.
Irwin KE, Jasin P, Braunstein KE, Sinha IR, Garret MA, Bowden KD, Chang K, Troncoso JC, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Miller T, Berry JD, Traynor BJ, Ling JP, Wong PC. Irwin KE, et al. Among authors: ling jp. Nat Med. 2024 Feb;30(2):382-393. doi: 10.1038/s41591-023-02788-5. Epub 2024 Jan 26. Nat Med. 2024. PMID: 38278991 Free PMC article.
Rodent models of TDP-43: recent advances.
Tsao W, Jeong YH, Lin S, Ling J, Price DL, Chiang PM, Wong PC. Tsao W, et al. Brain Res. 2012 Jun 26;1462:26-39. doi: 10.1016/j.brainres.2012.04.031. Epub 2012 May 1. Brain Res. 2012. PMID: 22608070 Free PMC article. Review.
PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.
Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC. Ling JP, et al. Cell Rep. 2016 Sep 27;17(1):104-113. doi: 10.1016/j.celrep.2016.08.071. Cell Rep. 2016. PMID: 27681424 Free PMC article.
Tdp-43 cryptic exons are highly variable between cell types.
Jeong YH, Ling JP, Lin SZ, Donde AN, Braunstein KE, Majounie E, Traynor BJ, LaClair KD, Lloyd TE, Wong PC. Jeong YH, et al. Among authors: ling jp. Mol Neurodegener. 2017 Feb 2;12(1):13. doi: 10.1186/s13024-016-0144-x. Mol Neurodegener. 2017. PMID: 28153034 Free PMC article.
Splicing repression is a major function of TDP-43 in motor neurons.
Donde A, Sun M, Ling JP, Braunstein KE, Pang B, Wen X, Cheng X, Chen L, Wong PC. Donde A, et al. Among authors: ling jp. Acta Neuropathol. 2019 Nov;138(5):813-826. doi: 10.1007/s00401-019-02042-8. Epub 2019 Jul 22. Acta Neuropathol. 2019. PMID: 31332509 Free PMC article.
30 results