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Page 1
mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
Uehara K, Lee WD, Stefkovich M, Biswas D, Santoleri D, Garcia Whitlock A, Quinn W 3rd, Coopersmith T, Creasy KT, Rader DJ, Sakamoto K, Rabinowitz JD, Titchenell PM. Uehara K, et al. Among authors: creasy kt. J Clin Invest. 2024 Jan 30;134(7):e173782. doi: 10.1172/JCI173782. J Clin Invest. 2024. PMID: 38290087 Free PMC article.
Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.
Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G. Salimando GJ, et al. Among authors: creasy kt. Nat Commun. 2023 Sep 13;14(1):5632. doi: 10.1038/s41467-023-41407-2. Nat Commun. 2023. PMID: 37704594 Free PMC article.
A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice.
Scorletti E, Saiman Y, Jeon S, Schneider CV, Buyco DG, Lin C, Himes BE, Mesaros CA, Vujkovic M, Creasy KT, Furth EE, Billheimer JT, Hand NJ, Kaplan DE, Chang KM, Tsao PS, Lynch JA, Dempsey JL, Harkin J, Bayen S, Conlon D, Guerraty M, Phillips MC, Rader DJ, Carr RM. Scorletti E, et al. Among authors: creasy kt. JHEP Rep. 2023 Oct 11;6(1):100902. doi: 10.1016/j.jhepr.2023.100902. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38074507 Free PMC article.
A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids.
Hehl L, Creasy KT, Vitali C, Scorletti E, Seeling KS, Vell MS, Rendel MD, Conlon D, Vujkovic M, Zandvakili I, Trautwein C, Schneider KM, Rader DJ, Schneider CV; Regeneron Genetics Center. Hehl L, et al. Among authors: creasy kt. Hepatol Commun. 2024 Apr 26;8(5):e0427. doi: 10.1097/HC9.0000000000000427. eCollection 2024 May 1. Hepatol Commun. 2024. PMID: 38668731 Free article.
The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.
Rendel MD, Vitali C, Creasy KT, Zhang D, Scorletti E, Huang H, Seeling KS, Park J, Hehl L, Vell MS, Conlon D, Hayat S; Regeneron Center; Phillips MC, Schneider KM, Rader DJ, Schneider CV. Rendel MD, et al. Among authors: creasy kt. Med. 2024 May 16:S2666-6340(24)00180-6. doi: 10.1016/j.medj.2024.04.010. Online ahead of print. Med. 2024. PMID: 38776916 Free article.
A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids.
Schneider CV, Hehl L, Creasy KT, Vitali C, Vell MS, Vujkovic M, Park J, Scorletti E, Seeling KS, Rendel MD, Conlon DM, Huang H, Zandvakili I, Valmiki S; Regeneron Center; Schneider KM, Hussain MM, Rader DJ. Schneider CV, et al. Among authors: creasy kt. Aliment Pharmacol Ther. 2023 Jul;58(2):238-249. doi: 10.1111/apt.17566. Epub 2023 May 29. Aliment Pharmacol Ther. 2023. PMID: 37248657
Large-scale identification of undiagnosed hepatic steatosis using natural language processing.
Schneider CV, Li T, Zhang D, Mezina AI, Rattan P, Huang H, Creasy KT, Scorletti E, Zandvakili I, Vujkovic M, Hehl L, Fiksel J, Park J, Wangensteen K, Risman M, Chang KM, Serper M, Carr RM, Schneider KM, Chen J, Rader DJ. Schneider CV, et al. Among authors: creasy kt. EClinicalMedicine. 2023 Aug 9;62:102149. doi: 10.1016/j.eclinm.2023.102149. eCollection 2023 Aug. EClinicalMedicine. 2023. PMID: 37599905 Free PMC article.
Aspirin is associated with a reduced incidence of liver disease in men.
Vell MS, Krishnan A, Wangensteen K, Serper M, Seeling KS, Hehl L, Rendel MD, Zandvakili I, Vujkovic M, Scorletti E, Creasy KT, Trautwein C, Rader DJ, Alqahtani S, Schneider KM, Schneider CV. Vell MS, et al. Among authors: creasy kt. Hepatol Commun. 2023 Sep 15;7(10):e0268. doi: 10.1097/HC9.0000000000000268. eCollection 2023 Oct 1. Hepatol Commun. 2023. PMID: 37708453 Free PMC article.
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.
Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program; Rader DJ, Voight BF, Chang KM. Vujkovic M, et al. Among authors: creasy kt. Nat Genet. 2022 Jun;54(6):761-771. doi: 10.1038/s41588-022-01078-z. Epub 2022 Jun 2. Nat Genet. 2022. PMID: 35654975 Free PMC article.
20 results