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Glycan-costumed virus-like particles promote type 1 anti-tumor immunity.
Lensch V, Gabba A, Hincapie R, Bhagchandani SH, Basak A, Alam MM, Irvine DJ, Shalek AK, Johnson JA, Finn MG, Kiessling LL. Lensch V, et al. Among authors: irvine dj. bioRxiv [Preprint]. 2024 Jan 18:2024.01.18.575711. doi: 10.1101/2024.01.18.575711. bioRxiv. 2024. PMID: 38293025 Free PMC article. Preprint.
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation.
Bhagchandani SH, Vohidov F, Milling LE, Tong EY, Brown CM, Ramseier ML, Liu B, Fessenden TB, Nguyen HV, Kiel GR, Won L, Langer RS, Spranger S, Shalek AK, Irvine DJ, Johnson JA. Bhagchandani SH, et al. Among authors: irvine dj. Sci Adv. 2023 Apr 21;9(16):eadg2239. doi: 10.1126/sciadv.adg2239. Epub 2023 Apr 19. Sci Adv. 2023. PMID: 37075115 Free PMC article.
Two-dose "extended priming" immunization amplifies humoral immune responses by synchronizing vaccine delivery with the germinal center response.
Bhagchandani SH, Yang L, Maiorino L, Ben-Akiva E, Rodrigues KA, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty AK, Irvine DJ. Bhagchandani SH, et al. Among authors: irvine dj. bioRxiv [Preprint]. 2023 Nov 21:2023.11.20.563479. doi: 10.1101/2023.11.20.563479. bioRxiv. 2023. PMID: 38045401 Free PMC article. Preprint.
Polymers at the Interface with Biology.
Deming TJ, Klok HA, Armes SP, Becker ML, Champion JA, Chen EY, Heilshorn SC, van Hest JCM, Irvine DJ, Johnson JA, Kiessling LL, Maynard HD, de la Cruz MO, Sullivan MO, Tirrell MV, Anseth KS, Lecommandoux S, Percec S, Zhong Z, Albertsson AC. Deming TJ, et al. Among authors: irvine dj. Biomacromolecules. 2018 Aug 13;19(8):3151-3162. doi: 10.1021/acs.biomac.8b01029. Biomacromolecules. 2018. PMID: 30099879 No abstract available.
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity.
Dane EL, Belessiotis-Richards A, Backlund C, Wang J, Hidaka K, Milling LE, Bhagchandani S, Melo MB, Wu S, Li N, Donahue N, Ni K, Ma L, Okaniwa M, Stevens MM, Alexander-Katz A, Irvine DJ. Dane EL, et al. Among authors: irvine dj. Nat Mater. 2022 Jun;21(6):710-720. doi: 10.1038/s41563-022-01251-z. Epub 2022 May 23. Nat Mater. 2022. PMID: 35606429 Free PMC article.
WASP facilitates tumor mechanosensitivity in T lymphocytes.
Mandal S, Melo M, Gordiichuk P, Acharya S, Poh YC, Li N, Aung A, Dane EL, Irvine DJ, Kumari S. Mandal S, et al. Among authors: irvine dj. bioRxiv [Preprint]. 2023 Oct 4:2023.10.02.560434. doi: 10.1101/2023.10.02.560434. bioRxiv. 2023. PMID: 37873483 Free PMC article. Preprint.
310 results