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Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity.
Shanley HT, Taki AC, Nguyen N, Wang T, Byrne JJ, Ang CS, Leeming MG, Nie S, Williamson N, Zheng Y, Young ND, Korhonen PK, Hofmann A, Chang BCH, Wells TNC, Häberli C, Keiser J, Jabbar A, Sleebs BE, Gasser RB. Shanley HT, et al. Among authors: wells tnc. Int J Parasitol Drugs Drug Resist. 2024 Apr;24:100522. doi: 10.1016/j.ijpddr.2024.100522. Epub 2024 Jan 23. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38295619 Free PMC article.
Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans.
Shanley HT, Taki AC, Nguyen N, Wang T, Byrne JJ, Ang CS, Leeming MG, Nie S, Williamson N, Zheng Y, Young ND, Korhonen PK, Hofmann A, Wells TNC, Jabbar A, Sleebs BE, Gasser RB. Shanley HT, et al. Among authors: wells tnc. Bioorg Med Chem. 2024 Jan 15;98:117540. doi: 10.1016/j.bmc.2023.117540. Epub 2023 Dec 3. Bioorg Med Chem. 2024. PMID: 38134663 Free article.
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication.
Policastro LR, Dolci I, Godoy AS, Silva Júnior JVJ, Ruiz UEA, Santos IA, Jardim ACG, Samby K, Burrows JN, Wells TNC, Gil LHVG, Oliva G, Fernandes RS. Policastro LR, et al. Among authors: wells tnc. Viruses. 2022 Jun 21;14(7):1351. doi: 10.3390/v14071351. Viruses. 2022. PMID: 35891332 Free PMC article.
Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro.
Jonsdottir HR, Siegrist D, Julien T, Padey B, Bouveret M, Terrier O, Pizzorno A, Huang S, Samby K, Wells TNC, Boda B, Rosa-Calatrava M, Engler OB, Constant S. Jonsdottir HR, et al. Among authors: wells tnc. Biomed Pharmacother. 2022 Jun;150:113058. doi: 10.1016/j.biopha.2022.113058. Epub 2022 May 2. Biomed Pharmacother. 2022. PMID: 35658229 Free PMC article.
The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks.
Samby K, Besson D, Dutta A, Patra B, Doy A, Glossop P, Mills J, Whitlock G, Hooft van Huijsduijnen R, Monaco A, Bilbe G, Mowbray C, Perry B, Adam A, Wells TNC, Willis PA. Samby K, et al. Among authors: wells tnc. ACS Infect Dis. 2022 Apr 8;8(4):713-720. doi: 10.1021/acsinfecdis.1c00527. Epub 2022 Mar 14. ACS Infect Dis. 2022. PMID: 35286809 Free PMC article.
Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus.
Belardinelli JM, Verma D, Li W, Avanzi C, Wiersma CJ, Williams JT, Johnson BK, Zimmerman M, Whittel N, Angala B, Wang H, Jones V, Dartois V, de Moura VCN, Gonzalez-Juarrero M, Pearce C, Schenkel AR, Malcolm KC, Nick JA, Charman SA, Wells TNC, Podell BK, Vennerstrom JL, Ordway DJ, Abramovitch RB, Jackson M. Belardinelli JM, et al. Among authors: wells tnc. Sci Transl Med. 2022 Feb 23;14(633):eabj3860. doi: 10.1126/scitranslmed.abj3860. Epub 2022 Feb 23. Sci Transl Med. 2022. PMID: 35196022 Free PMC article.
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. Adoke Y, et al. Among authors: wells tnc. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4. Malar J. 2021. PMID: 34011358 Free PMC article. Clinical Trial.
78 results