Griffin MDW - Search Results

1

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.

Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. Xie SC, et al. Among authors: griffin mdw. Nat Commun. 2024 Jan 31;15(1):937. doi: 10.1038/s41467-024-45224-z. Nat Commun. 2024. PMID: 38297033 Free PMC article.

2

Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax.

Voss JE, Scally SW, Taylor NL, Atkinson SC, Griffin MD, Hutton CA, Parker MW, Alderton MR, Gerrard JA, Dobson RC, Dogovski C, Perugini MA. Voss JE, et al. J Biol Chem. 2010 Feb 19;285(8):5188-95. doi: 10.1074/jbc.M109.038166. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948665 Free PMC article.

3

A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking.

McHugh E, Batinovic S, Hanssen E, McMillan PJ, Kenny S, Griffin MD, Crawford S, Trenholme KR, Gardiner DL, Dixon MW, Tilley L. McHugh E, et al. Mol Microbiol. 2015 Dec;98(6):1101-14. doi: 10.1111/mmi.13201. Epub 2015 Sep 25. Mol Microbiol. 2015. PMID: 26304012 Free PMC article.

4

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum.

Pasaje CF, Cheung V, Kennedy K, Lim EE, Baell JB, Griffin MD, Ralph SA. Pasaje CF, et al. Sci Rep. 2016 Jun 9;6:27531. doi: 10.1038/srep27531. Sci Rep. 2016. PMID: 27277538 Free PMC article.

5

Unravelling the Carbohydrate-Binding Preferences of the Carbohydrate-Binding Modules of AMP-Activated Protein Kinase.

Mobbs JI, Di Paolo A, Metcalfe RD, Selig E, Stapleton DI, Griffin MDW, Gooley PR. Mobbs JI, et al. Among authors: griffin mdw. Chembiochem. 2018 Feb 2;19(3):229-238. doi: 10.1002/cbic.201700589. Epub 2018 Jan 9. Chembiochem. 2018. PMID: 29193585

6

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA. Atkinson SC, et al. Among authors: griffin mdw. Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24. Structure. 2018. PMID: 29804823 Free article.

7

Cryo-EM structure of an essential Plasmodium vivax invasion complex.

Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH. Gruszczyk J, et al. Among authors: griffin mdw. Nature. 2018 Jul;559(7712):135-139. doi: 10.1038/s41586-018-0249-1. Epub 2018 Jun 27. Nature. 2018. PMID: 29950717

8

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.

Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L. Xie SC, et al. Among authors: griffin mdw. Nat Microbiol. 2019 Nov;4(11):1990-2000. doi: 10.1038/s41564-019-0524-4. Epub 2019 Aug 5. Nat Microbiol. 2019. PMID: 31384003

9

The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.

Metcalfe RD, Aizel K, Zlatic CO, Nguyen PM, Morton CJ, Lio DS, Cheng HC, Dobson RCJ, Parker MW, Gooley PR, Putoczki TL, Griffin MDW. Metcalfe RD, et al. Among authors: griffin mdw. J Biol Chem. 2020 Jun 12;295(24):8285-8301. doi: 10.1074/jbc.RA119.012351. Epub 2020 Apr 24. J Biol Chem. 2020. PMID: 32332100 Free PMC article.

10

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.

Metcalfe RD, Putoczki TL, Griffin MDW. Metcalfe RD, et al. Among authors: griffin mdw. Front Immunol. 2020 Jul 16;11:1424. doi: 10.3389/fimmu.2020.01424. eCollection 2020. Front Immunol. 2020. PMID: 32765502 Free PMC article. Review.

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