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Page 1
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. Xie SC, et al. Among authors: klug dm. Nat Commun. 2024 Jan 31;15(1):937. doi: 10.1038/s41467-024-45224-z. Nat Commun. 2024. PMID: 38297033 Free PMC article.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. Xie SC, et al. Among authors: klug dm. Res Sq [Preprint]. 2023 Jul 27:rs.3.rs-3198291. doi: 10.21203/rs.3.rs-3198291/v1. Res Sq. 2023. PMID: 37546892 Free PMC article. Updated. Preprint.
Open science approaches to COVID-19.
Tse EG, Klug DM, Todd MH. Tse EG, et al. Among authors: klug dm. F1000Res. 2020 Aug 25;9:1043. doi: 10.12688/f1000research.26084.1. eCollection 2020. F1000Res. 2020. PMID: 33145011 Free PMC article. Review.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. Singh B, et al. Among authors: klug dm. ACS Med Chem Lett. 2020 Jan 10;11(3):249-257. doi: 10.1021/acsmedchemlett.9b00453. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184953 Free PMC article.
Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.
Dichiara M, Simpson QJ, Quotadamo A, Jalani HB, Huang AX, Millard CC, Klug DM, Tse EG, Todd MH, Silva DG, da Silva Emery F, Carlson JE, Zheng SL, Vleminckx M, Matheeussen A, Caljon G, Pollastri MP, Sjö P, Perry B, Ferrins L. Dichiara M, et al. Among authors: klug dm. ACS Infect Dis. 2023 Aug 11;9(8):1470-1487. doi: 10.1021/acsinfecdis.3c00040. Epub 2023 Jul 7. ACS Infect Dis. 2023. PMID: 37417544 Free PMC article.
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus.
Klug DM, Tse EG, Silva DG, Cao Y, Charman SA, Chauhan J, Crighton E, Dichiara M, Drake C, Drewry D, da Silva Emery F, Ferrins L, Graves L, Hopkins E, Kresina TAC, Lorente-Macías Á, Perry B, Phipps R, Quiroga B, Quotadamo A, Sabatino GN, Sama A, Schätzlein A, Simpson QJ, Steele J, Shanu-Wilson J, Sjö P, Stapleton P, Swain CJ, Vaideanu A, Xie H, Zuercher W, Todd MH. Klug DM, et al. ACS Infect Dis. 2023 Dec 8;9(12):2423-2435. doi: 10.1021/acsinfecdis.3c00286. Epub 2023 Nov 22. ACS Infect Dis. 2023. PMID: 37991879 Free PMC article.
Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni.
Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. Buskes MJ, et al. Among authors: klug dm. ACS Med Chem Lett. 2020 Jan 10;11(3):258-265. doi: 10.1021/acsmedchemlett.9b00455. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184954 Free PMC article.
Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes MJ, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, Ferrins L. Bachovchin KA, et al. Among authors: klug dm. J Med Chem. 2019 Jan 24;62(2):665-687. doi: 10.1021/acs.jmedchem.8b01365. Epub 2019 Jan 10. J Med Chem. 2019. PMID: 30565932 Free PMC article.
Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.
Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, Pollastri MP. Klug DM, et al. PLoS Negl Trop Dis. 2019 Feb 8;13(2):e0007129. doi: 10.1371/journal.pntd.0007129. eCollection 2019 Feb. PLoS Negl Trop Dis. 2019. PMID: 30735501 Free PMC article.
17 results