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KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y, Le D, Spina S, Grinberg LT, Seeley WW, Kramer JH, Sacktor TC, Schilling B, Gan L, Casaletto KB, Tracy TE. Kauwe G, et al. Among authors: gan l. J Clin Invest. 2024 Feb 1;134(3):e169064. doi: 10.1172/JCI169064. J Clin Invest. 2024. PMID: 38299587 Free PMC article.
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Min SW, et al. Among authors: gan l. Neuron. 2010 Sep 23;67(6):953-66. doi: 10.1016/j.neuron.2010.08.044. Neuron. 2010. PMID: 20869593 Free PMC article.
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.
Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Grinberg LT, et al. Among authors: gan l. Acta Neuropathol. 2013 Apr;125(4):581-93. doi: 10.1007/s00401-013-1080-2. Epub 2013 Jan 31. Acta Neuropathol. 2013. PMID: 23371364 Free PMC article.
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L. Ward ME, et al. Among authors: gan l. J Exp Med. 2014 Sep 22;211(10):1937-45. doi: 10.1084/jem.20140214. Epub 2014 Aug 25. J Exp Med. 2014. PMID: 25155018 Free PMC article.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Min SW, et al. Among authors: gan l. Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. Nat Med. 2015. PMID: 26390242 Free PMC article.
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.
Tracy TE, Gan L. Tracy TE, et al. Among authors: gan l. Bioessays. 2017 Apr;39(4):10.1002/bies.201600224. doi: 10.1002/bies.201600224. Epub 2017 Jan 13. Bioessays. 2017. PMID: 28083916 Free PMC article. Review.
3,060 results