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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2317756121. doi: 10.1073/pnas.2317756121. Epub 2024 Feb 1.
Proc Natl Acad Sci U S A. 2024.
PMID: 38300868
Free PMC article.
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Subbiah V, Sahai V, Maglic D, Bruderek K, Touré BB, Zhao S, Valverde R, O'Hearn PJ, Moustakas DT, Schönherr H, Gerami-Moayed N, Taylor AM, Hudson BM, Houde DJ, Pal D, Foster L, Gunaydin H, Ayaz P, Sharon DA, Goyal L, Schram AM, Kamath S, Sherwin CA, Schmidt-Kittler O, Jen KY, Ricard F, Wolf BB, Shaw DE, Bergstrom DA, Watters J, Casaletto JB.
Subbiah V, et al. Among authors: casaletto jb.
Cancer Discov. 2023 Sep 6;13(9):2012-2031. doi: 10.1158/2159-8290.CD-23-0475.
Cancer Discov. 2023.
PMID: 37270847
Free PMC article.
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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Casaletto JB, Geddie ML, Abu-Yousif AO, Masson K, Fulgham A, Boudot A, Maiwald T, Kearns JD, Kohli N, Su S, Razlog M, Raue A, Kalra A, Håkansson M, Logan DT, Welin M, Chattopadhyay S, Harms BD, Nielsen UB, Schoeberl B, Lugovskoy AA, MacBeath G.
Casaletto JB, et al.
Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7533-7542. doi: 10.1073/pnas.1819085116. Epub 2019 Mar 21.
Proc Natl Acad Sci U S A. 2019.
PMID: 30898885
Free PMC article.
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Merlin/ERM proteins establish cortical asymmetry and centrosome position.
Hebert AM, DuBoff B, Casaletto JB, Gladden AB, McClatchey AI.
Hebert AM, et al. Among authors: casaletto jb.
Genes Dev. 2012 Dec 15;26(24):2709-23. doi: 10.1101/gad.194027.112.
Genes Dev. 2012.
PMID: 23249734
Free PMC article.
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Spatial regulation of receptor tyrosine kinases in development and cancer.
Casaletto JB, McClatchey AI.
Casaletto JB, et al.
Nat Rev Cancer. 2012 May 24;12(6):387-400. doi: 10.1038/nrc3277.
Nat Rev Cancer. 2012.
PMID: 22622641
Free PMC article.
Review.
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Ezrin-mediated apical integrity is required for intestinal homeostasis.
Casaletto JB, Saotome I, Curto M, McClatchey AI.
Casaletto JB, et al.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11924-9. doi: 10.1073/pnas.1103418108. Epub 2011 Jul 5.
Proc Natl Acad Sci U S A. 2011.
PMID: 21730140
Free PMC article.
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Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase.
Casaletto JB, Nutt LK, Wu Q, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S.
Casaletto JB, et al.
J Cell Biol. 2005 Apr 11;169(1):61-71. doi: 10.1083/jcb.200411056.
J Cell Biol. 2005.
PMID: 15824132
Free PMC article.
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