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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Schönherr H, Ayaz P, Taylor AM, Casaletto JB, Touré BB, Moustakas DT, Hudson BM, Valverde R, Zhao S, O'Hearn PJ, Foster L, Sharon DA, Garfinkle S, Giordanetto F, Lescarbeau A, Kurukulasuriya R, Gerami-Moayed N, Maglic D, Bruderek K, Naik G, Gunaydin H, Mader MM, Boezio AA, McLean TH, Chen R, Wang Y, Shaw DE, Watters J, Bergstrom DA. Schönherr H, et al. Among authors: garfinkle s. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2317756121. doi: 10.1073/pnas.2317756121. Epub 2024 Feb 1. Proc Natl Acad Sci U S A. 2024. PMID: 38300868 Free PMC article.
Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.
Campbell MR, Ruiz-Saenz A, Peterson E, Agnew C, Ayaz P, Garfinkle S, Littlefield P, Steri V, Oeffinger J, Sampang M, Shan Y, Shaw DE, Jura N, Moasser MM. Campbell MR, et al. Among authors: garfinkle s. Cell Rep. 2022 Feb 1;38(5):110291. doi: 10.1016/j.celrep.2021.110291. Cell Rep. 2022. PMID: 35108525 Free PMC article.
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion.
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sun Y, et al. Among authors: garfinkle se. Sci Immunol. 2023 Dec;8(90):eadj5792. doi: 10.1126/sciimmunol.adj5792. Epub 2023 Dec 1. Sci Immunol. 2023. PMID: 38039376 Free PMC article.
Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion.
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sun Y, et al. Among authors: garfinkle se. bioRxiv [Preprint]. 2023 May 24:2023.05.24.542108. doi: 10.1101/2023.05.24.542108. bioRxiv. 2023. PMID: 37292750 Free PMC article. Updated. Preprint.
Testing of a Program to Automatically Analyze Students' Concept Maps.
Hubal R, Bobbitt L, Garfinkle S, Harris SC, Powell BD, Oxley MS, Anksorus HN, Chen KY. Hubal R, et al. Among authors: garfinkle s. Pharmacy (Basel). 2020 Nov 7;8(4):209. doi: 10.3390/pharmacy8040209. Pharmacy (Basel). 2020. PMID: 33171850 Free PMC article.
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization.
Biegasiewicz KF, Cooper SJ, Gao X, Oblinsky DG, Kim JH, Garfinkle SE, Joyce LA, Sandoval BA, Scholes GD, Hyster TK. Biegasiewicz KF, et al. Among authors: garfinkle se. Science. 2019 Jun 21;364(6446):1166-1169. doi: 10.1126/science.aaw1143. Science. 2019. PMID: 31221855 Free PMC article.
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