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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2317756121. doi: 10.1073/pnas.2317756121. Epub 2024 Feb 1.
Proc Natl Acad Sci U S A. 2024.
PMID: 38300868
Free PMC article.
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Subbiah V, Sahai V, Maglic D, Bruderek K, Touré BB, Zhao S, Valverde R, O'Hearn PJ, Moustakas DT, Schönherr H, Gerami-Moayed N, Taylor AM, Hudson BM, Houde DJ, Pal D, Foster L, Gunaydin H, Ayaz P, Sharon DA, Goyal L, Schram AM, Kamath S, Sherwin CA, Schmidt-Kittler O, Jen KY, Ricard F, Wolf BB, Shaw DE, Bergstrom DA, Watters J, Casaletto JB.
Subbiah V, et al. Among authors: sharon da.
Cancer Discov. 2023 Sep 6;13(9):2012-2031. doi: 10.1158/2159-8290.CD-23-0475.
Cancer Discov. 2023.
PMID: 37270847
Free PMC article.
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Water orientation and dynamics in the closed and open influenza B virus M2 proton channels.
Gelenter MD, Mandala VS, Niesen MJM, Sharon DA, Dregni AJ, Willard AP, Hong M.
Gelenter MD, et al. Among authors: sharon da.
Commun Biol. 2021 Mar 12;4(1):338. doi: 10.1038/s42003-021-01847-2.
Commun Biol. 2021.
PMID: 33712696
Free PMC article.
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Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates.
Latham AP, Zhu L, Sharon DA, Ye S, Willard AP, Zhang X, Zhang B.
Latham AP, et al. Among authors: sharon da.
bioRxiv [Preprint]. 2024 Mar 28:2023.03.30.534967. doi: 10.1101/2023.03.30.534967.
bioRxiv. 2024.
PMID: 37034777
Free PMC article.
Preprint.
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Computation Sheds Insight into Iron Porphyrin Carbenes' Electronic Structure, Formation, and N-H Insertion Reactivity.
Sharon DA, Mallick D, Wang B, Shaik S.
Sharon DA, et al.
J Am Chem Soc. 2016 Aug 3;138(30):9597-610. doi: 10.1021/jacs.6b04636. Epub 2016 Jul 20.
J Am Chem Soc. 2016.
PMID: 27347808
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