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Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas.
bioRxiv [Preprint]. 2024 May 6:2024.05.03.592420. doi: 10.1101/2024.05.03.592420.
bioRxiv. 2024.
PMID: 38766189
Free PMC article.
Preprint.
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy.
Kazansky Y, Cameron D, Mueller HS, Demarest P, Zaffaroni N, Arrighetti N, Zuco V, Kuwahara Y, Somwar R, Ladanyi M, Qu R, de Stanchina E, Dela Cruz FS, Kung AL, Gounder MM, Kentsis A.
Kazansky Y, et al.
Cancer Discov. 2024 Feb 5. doi: 10.1158/2159-8290.CD-23-0110. Online ahead of print.
Cancer Discov. 2024.
PMID: 38315003
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Epigenetic Cooperativity as a Therapeutic Vulnerability in Cancer.
Kazansky Y, Kentsis A.
Kazansky Y, et al.
Cancer Res. 2023 Dec 1;83(23):3827-3829. doi: 10.1158/0008-5472.CAN-23-2924.
Cancer Res. 2023.
PMID: 38037453
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Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy.
Kazansky Y, Cameron D, Mueller HS, Demarest P, Zaffaroni N, Arrighetti N, Zuco V, Kuwahara Y, Somwar R, Ladanyi M, Qu R, De Stanchina E, Dela Cruz FS, Kung AL, Gounder M, Kentsis A.
Kazansky Y, et al.
bioRxiv [Preprint]. 2023 Dec 1:2023.02.06.527192. doi: 10.1101/2023.02.06.527192.
bioRxiv. 2023.
PMID: 36798379
Free PMC article.
Updated.
Preprint.
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The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA.
Heikamp EB, et al. Among authors: kazansky y.
Blood. 2022 Feb 10;139(6):894-906. doi: 10.1182/blood.2021012806.
Blood. 2022.
PMID: 34582559
Free PMC article.
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Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG.
Minuesa G, et al. Among authors: kazansky y.
Nat Commun. 2019 Jun 19;10(1):2691. doi: 10.1038/s41467-019-10523-3.
Nat Commun. 2019.
PMID: 31217428
Free PMC article.
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Impact of different ionization states of phosphorylated Serine-65 on ubiquitin structure and interactions.
Kazansky Y, Lai MY, Singh RK, Fushman D.
Kazansky Y, et al.
Sci Rep. 2018 Feb 8;8(1):2651. doi: 10.1038/s41598-018-20860-w.
Sci Rep. 2018.
PMID: 29422536
Free PMC article.
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Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.
Singh RK, Kazansky Y, Wathieu D, Fushman D.
Singh RK, et al. Among authors: kazansky y.
Anal Chem. 2017 Aug 1;89(15):7852-7860. doi: 10.1021/acs.analchem.6b04194. Epub 2017 Jul 20.
Anal Chem. 2017.
PMID: 28686836
Free PMC article.
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