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Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy.
Kazansky Y, Cameron D, Mueller HS, Demarest P, Zaffaroni N, Arrighetti N, Zuco V, Kuwahara Y, Somwar R, Ladanyi M, Qu R, de Stanchina E, Dela Cruz FS, Kung AL, Gounder MM, Kentsis A. Kazansky Y, et al. Among authors: kuwahara y. Cancer Discov. 2024 Feb 5. doi: 10.1158/2159-8290.CD-23-0110. Online ahead of print. Cancer Discov. 2024. PMID: 38315003
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Henssen AG, et al. Among authors: kuwahara y. Sci Transl Med. 2017 Nov 1;9(414):eaam9078. doi: 10.1126/scitranslmed.aam9078. Sci Transl Med. 2017. PMID: 29093183 Free PMC article.
Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors.
Shinohara H, Sawado R, Nakagawa M, Hattori A, Yamagata K, Tauchi K, Ito J, Kuwahara Y, Okuda T, Ogawa C, Kitabayashi I. Shinohara H, et al. Among authors: kuwahara y. Mol Ther Oncolytics. 2022 Sep 19;27:14-25. doi: 10.1016/j.omto.2022.09.006. eCollection 2022 Dec 15. Mol Ther Oncolytics. 2022. PMID: 36212776 Free PMC article.
Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells.
Ouchi K, Miyachi M, Yagyu S, Kikuchi K, Kuwahara Y, Tsuchiya K, Iehara T, Hosoi H. Ouchi K, et al. Among authors: kuwahara y. Cancer Cell Int. 2020 May 24;20:192. doi: 10.1186/s12935-020-01282-z. eCollection 2020. Cancer Cell Int. 2020. PMID: 32489328 Free PMC article.
583 results