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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Crespo-Garcia S, et al. Among authors: rezende fa. Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6. Nat Med. 2024. PMID: 38321220 Clinical Trial.
NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.
Miloudi K, Oubaha M, Ménard C, Dejda A, Guber V, Cagnone G, Wilson AM, Tétreault N, Mawambo G, Binet F, Chidiac R, Delisle C, Buscarlet M, Cerani A, Crespo-Garcia S, Bentley K, Rezende F, Joyal JS, Mallette FA, Gratton JP, Larrivée B, Sapieha P. Miloudi K, et al. Among authors: rezende f. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20. Proc Natl Acad Sci U S A. 2019. PMID: 30787185 Free PMC article.
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.
Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F, Joyal JS, Mallette FA, Sapieha P. Binet F, et al. Among authors: rezende fa. Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356. Science. 2020. PMID: 32820093
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Joyal JS, et al. Among authors: rezende fa. Nat Med. 2016 Apr;22(4):439-45. doi: 10.1038/nm.4059. Epub 2016 Mar 14. Nat Med. 2016. PMID: 26974308 Free PMC article.
Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation.
Andriessen EMMA, Binet F, Fournier F, Hata M, Dejda A, Mawambo G, Crespo-Garcia S, Pilon F, Buscarlet M, Beauchemin K, Bougie V, Cumberlidge G, Wilson AM, Bourgault S, Rezende FA, Beaulieu N, Delisle JS, Sapieha P. Andriessen EMMA, et al. Among authors: rezende fa. EMBO Mol Med. 2021 May 7;13(5):e11754. doi: 10.15252/emmm.201911754. Epub 2021 Apr 19. EMBO Mol Med. 2021. PMID: 33876574 Free PMC article.
56 results