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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
Daily KP, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan MH, Carafice C, Krause K, McNamara A, Hamilton K, Houle S, Gupta S, Gupta GA, Madhu S, Fitzgerald J, Saadey AA, Laster B, Yan P, Webb A, Zhang X, Pietrzak M, Kokiko-Cochran ON, Ghoneim HE, Amer AO. Daily KP, et al. Among authors: zhang x. Alzheimers Res Ther. 2024 Feb 8;16(1):29. doi: 10.1186/s13195-024-01390-2. Alzheimers Res Ther. 2024. PMID: 38326859 Free PMC article.
CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection.
Krause K, Caution K, Badr A, Hamilton K, Saleh A, Patel K, Seveau S, Hall-Stoodley L, Hegazi R, Zhang X, Gavrilin MA, Amer AO. Krause K, et al. Among authors: zhang x. Autophagy. 2018;14(11):1928-1942. doi: 10.1080/15548627.2018.1491494. Epub 2018 Aug 31. Autophagy. 2018. PMID: 30165781 Free PMC article.
Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo.
Estfanous S, Krause K, Anne MNK, Eltobgy M, Caution K, Abu Khweek A, Hamilton K, Badr A, Daily K, Carafice C, Baetzhold D, Zhang X, Li T, Wen H, Gavrilin MA, Haffez H, Soror S, Amer AO. Estfanous S, et al. Among authors: zhang x. Sci Rep. 2021 Jan 13;11(1):855. doi: 10.1038/s41598-020-79201-5. Sci Rep. 2021. PMID: 33441602 Free PMC article.
Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation.
Estfanous S, Daily KP, Eltobgy M, Deems NP, Anne MNK, Krause K, Badr A, Hamilton K, Carafice C, Hegazi A, Abu Khweek A, Kelani H, Nimjee S, Awad H, Zhang X, Cormet-Boyaka E, Haffez H, Soror S, Mikhail A, Nuovo G, Barrientos RM, Gavrilin MA, Amer AO. Estfanous S, et al. Among authors: zhang x. Front Immunol. 2021 Jul 27;12:705581. doi: 10.3389/fimmu.2021.705581. eCollection 2021. Front Immunol. 2021. PMID: 34426734 Free PMC article.
Caspase-11 regulates lung inflammation in response to house dust mites.
Abu Khweek A, Joldrichsen MR, Kim E, Attia Z, Krause K, Daily K, Estfanous S, Hamilton K, Badr A, Anne MNK, Eltobgy M, Corps KN, Carafice C, Zhang X, Gavrilin MA, Boyaka PN, Amer AO. Abu Khweek A, et al. Among authors: zhang x. Cell Immunol. 2021 Dec;370:104425. doi: 10.1016/j.cellimm.2021.104425. Epub 2021 Aug 29. Cell Immunol. 2021. PMID: 34800762 Free PMC article.
Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Eltobgy MM, et al. Among authors: zhang x. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2202012119. doi: 10.1073/pnas.2202012119. Epub 2022 May 19. Proc Natl Acad Sci U S A. 2022. PMID: 35588457 Free PMC article.
Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation.
Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caution K, et al. Among authors: zhang x. Front Immunol. 2019 Nov 15;10:2519. doi: 10.3389/fimmu.2019.02519. eCollection 2019. Front Immunol. 2019. PMID: 31803174 Free PMC article.
Defective immunometabolism pathways in cystic fibrosis macrophages.
Hamilton K, Krause K, Badr A, Daily K, Estfanous S, Eltobgy M, Khweek AA, Anne MNK, Carafice C, Baetzhold D, Tonniges JR, Zhang X, Gavrilin MA, Parinandi NL, Amer AO. Hamilton K, et al. Among authors: zhang x. J Cyst Fibros. 2021 Jul;20(4):664-672. doi: 10.1016/j.jcf.2020.10.006. Epub 2020 Nov 15. J Cyst Fibros. 2021. PMID: 33208300 Free PMC article.
Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo.
Estfanous S, Krause K, Anne MNK, Eltobgy M, Caution K, Khweek AA, Hamilton K, Badr A, Daily K, Carafice C, Baetzhold D, Zhang X, Li T, Wen H, Gavrilin MA, Haffez H, Soror S, Amer AO. Estfanous S, et al. Among authors: zhang x. Sci Rep. 2021 Jun 8;11(1):12447. doi: 10.1038/s41598-021-92047-9. Sci Rep. 2021. PMID: 34103646 Free PMC article. No abstract available.
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