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Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission.
Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Kotha S, Kuo G, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, Workman CJ, Vignali DAA, Pletinkova O, Jia H, Peng W, Nauen DW, Wong PC, Redding-Ochoa J, Troncoso JC, Ying M, Dawson VL, Dawson TM, Mao X. Chen C, et al. Among authors: chen r. Adv Sci (Weinh). 2024 Apr;11(16):e2303775. doi: 10.1002/advs.202303775. Epub 2024 Feb 7. Adv Sci (Weinh). 2024. PMID: 38327094 Free PMC article.
Pathological Tau transmission initiated by binding lymphocyte-activation gene 3.
Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, Workman CJ, Vignali DAA, Pletinkova O, Nauen DW, Wong PC, Troncoso JC, Ying M, Dawson VL, Dawson TM, Mao X. Chen C, et al. Among authors: chen r. bioRxiv [Preprint]. 2023 May 17:2023.05.16.541015. doi: 10.1101/2023.05.16.541015. bioRxiv. 2023. Update in: Adv Sci (Weinh). 2024 Apr;11(16):e2303775. doi: 10.1002/advs.202303775. PMID: 37293032 Free PMC article. Updated. Preprint.
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.
Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. Mao X, et al. Among authors: chen r. Science. 2016 Sep 30;353(6307):aah3374. doi: 10.1126/science.aah3374. Science. 2016. PMID: 27708076 Free PMC article.
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease.
Khan MR, Yin X, Kang SU, Mitra J, Wang H, Ryu T, Brahmachari S, Karuppagounder SS, Kimura Y, Jhaldiyal A, Kim HH, Gu H, Chen R, Redding-Ochoa J, Troncoso J, Na CH, Ha T, Dawson VL, Dawson TM. Khan MR, et al. Among authors: chen r. Sci Transl Med. 2023 Nov 29;15(724):eadd0499. doi: 10.1126/scitranslmed.add0499. Epub 2023 Nov 29. Sci Transl Med. 2023. PMID: 38019930
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy.
Hinkle JT, Patel J, Panicker N, Karuppagounder SS, Biswas D, Belingon B, Chen R, Brahmachari S, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. Hinkle JT, et al. Among authors: chen r. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2118819119. doi: 10.1073/pnas.2118819119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394877 Free PMC article.
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.
Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. Kam TI, et al. Among authors: chen r. Science. 2018 Nov 2;362(6414):eaat8407. doi: 10.1126/science.aat8407. Science. 2018. PMID: 30385548 Free PMC article.
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