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Page 1
Mannose-coupled AAV2: A second-generation AAV vector for increased retinal gene therapy efficiency.
Mével M, Pichard V, Bouzelha M, Alvarez-Dorta D, Lalys PA, Provost N, Allais M, Mendes A, Landagaray E, Ducloyer JB, Toublanc E, Galy A, Brument N, Lefevre GM, Gouin SG, Isiegas C, Le Meur G, Cronin T, Le Guiner C, Weber M, Moullier P, Ayuso E, Deniaud D, Adjali O. Mével M, et al. Among authors: le guiner c. Mol Ther Methods Clin Dev. 2024 Jan 17;32(1):101187. doi: 10.1016/j.omtm.2024.101187. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38327809 Free PMC article.
Intravitreal air tamponade after AAV2 subretinal injection modifies retinal EGFP distribution.
Ducloyer JB, Pichard V, Mevel M, Galy A, Lefevre GM, Brument N, Alvarez-Dorta D, Deniaud D, Mendes-Madeira A, Libeau L, Le Guiner C, Cronin T, Adjali O, Weber M, Le Meur G. Ducloyer JB, et al. Among authors: le guiner c. Mol Ther Methods Clin Dev. 2023 Feb 15;28:387-393. doi: 10.1016/j.omtm.2023.02.006. eCollection 2023 Mar 9. Mol Ther Methods Clin Dev. 2023. PMID: 36874242 Free PMC article.
AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation.
Gernoux G, Guilbaud M, Devaux M, Journou M, Pichard V, Jaulin N, Léger A, Le Duff J, Deschamps JY, Le Guiner C, Moullier P, Cherel Y, Adjali O. Gernoux G, et al. Among authors: le duff j, le guiner c. Mol Ther Methods Clin Dev. 2021 Feb 6;20:660-674. doi: 10.1016/j.omtm.2021.02.003. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2021. PMID: 33718516 Free PMC article.
Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy.
Le Guiner C, Xiao X, Larcher T, Lafoux A, Huchet C, Toumaniantz G, Adjali O, Anegon I, Remy S, Grieger J, Li J, Farrokhi V, Neubert H, Owens J, McIntyre M, Moullier P, Samulski RJ. Le Guiner C, et al. Mol Ther Methods Clin Dev. 2023 May 18;30:30-47. doi: 10.1016/j.omtm.2023.05.017. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37746247 Free PMC article.
Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina.
Leray A, Lalys PA, Varin J, Bouzelha M, Bourdon A, Alvarez-Dorta D, Pavageau K, Depienne S, Marchand M, Mellet A, Demilly J, Ducloyer JB, Girard T, Fraysse B, Ledevin M, Guilbaud M, Gouin SG, Ayuso E, Adjali O, Larcher T, Cronin T, Le Guiner C, Deniaud D, Mével M. Leray A, et al. Among authors: le guiner c. Biomed Pharmacother. 2024 Feb;171:116148. doi: 10.1016/j.biopha.2024.116148. Epub 2024 Jan 16. Biomed Pharmacother. 2024. PMID: 38232661 Free article.
Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model.
Bourdon A, François V, Zhang L, Lafoux A, Fraysse B, Toumaniantz G, Larcher T, Girard T, Ledevin M, Lebreton C, Hivonnait A, Creismeas A, Allais M, Marie B, Guguin J, Blouin V, Remy S, Anegon I, Huchet C, Malerba A, Kao B, Le Heron A, Moullier P, Dickson G, Popplewell L, Adjali O, Montanaro F, Le Guiner C. Bourdon A, et al. Among authors: le guiner c. Gene Ther. 2022 Sep;29(9):520-535. doi: 10.1038/s41434-022-00317-6. Epub 2022 Feb 1. Gene Ther. 2022. PMID: 35105949
Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA.
Dupont JB, Tournaire B, Georger C, Marolleau B, Jeanson-Leh L, Ledevin M, Lindenbaum P, Lecomte E, Cogné B, Dubreil L, Larcher T, Gjata B, Van Wittenberghe L, Le Guiner C, Penaud-Budloo M, Snyder RO, Moullier P, Léger A. Dupont JB, et al. Among authors: le guiner c. Mol Ther Methods Clin Dev. 2015 Apr 8;2:15010. doi: 10.1038/mtm.2015.10. eCollection 2015. Mol Ther Methods Clin Dev. 2015. PMID: 26029721 Free PMC article.
Five Years of Successful Inducible Transgene Expression Following Locoregional Adeno-Associated Virus Delivery in Nonhuman Primates with No Detectable Immunity.
Guilbaud M, Devaux M, Couzinié C, Le Duff J, Toromanoff A, Vandamme C, Jaulin N, Gernoux G, Larcher T, Moullier P, Le Guiner C, Adjali O. Guilbaud M, et al. Among authors: le duff j, le guiner c. Hum Gene Ther. 2019 Jul;30(7):802-813. doi: 10.1089/hum.2018.234. Epub 2019 Apr 16. Hum Gene Ther. 2019. PMID: 30808235 Free PMC article.
47 results