O'Brien RM - Search Results

1

Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model.

Sinclair M, Stein RA, Sheehan JH, Hawes EM, O'Brien RM, Tajkhorshid E, Claxton DP. Sinclair M, et al. Among authors: o brien rm. PNAS Nexus. 2024 Jan 29;3(2):pgae036. doi: 10.1093/pnasnexus/pgae036. eCollection 2024 Feb. PNAS Nexus. 2024. PMID: 38328777 Free PMC article.

2

Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1.

Claxton DP, Overway EM, Oeser JK, O'Brien RM, Mchaourab HS. Claxton DP, et al. J Biol Chem. 2022 Jan;298(1):101520. doi: 10.1016/j.jbc.2021.101520. Epub 2021 Dec 21. J Biol Chem. 2022. PMID: 34952005 Free PMC article.

3

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.

Overway EM, Bosma KJ, Claxton DP, Oeser JK, Singh K, Breidenbach LB, Mchaourab HS, Davis LK, O'Brien RM. Overway EM, et al. J Biol Chem. 2022 Feb;298(2):101534. doi: 10.1016/j.jbc.2021.101534. Epub 2021 Dec 23. J Biol Chem. 2022. PMID: 34954144 Free PMC article.

4

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.

Keller MP, Hawes EM, Schueler KL, Stapleton DS, Mitok KA, Simonett SP, Oeser JK, Sampson LL, Attie AD, Magnuson MA, O'Brien RM. Keller MP, et al. Among authors: o brien rm. Diabetes. 2023 Nov 1;72(11):1621-1628. doi: 10.2337/db23-0215. Diabetes. 2023. PMID: 37552875

5

G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.

Hawes EM, Boortz KA, Oeser JK, O'Rourke ML, O'Brien RM. Hawes EM, et al. Among authors: o brien rm. J Mol Endocrinol. 2023 Oct 18;71(4):e230070. doi: 10.1530/JME-23-0070. Print 2023 Nov 1. J Mol Endocrinol. 2023. PMID: 37855366

6

Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model.

Hawes EM, Claxton DP, Oeser JK, O'Brien RM. Hawes EM, et al. Among authors: o brien rm. Biosci Rep. 2024 Jan 31;44(1):BSR20231851. doi: 10.1042/BSR20231851. Biosci Rep. 2024. PMID: 38095063 Free PMC article.

7

Biochemical and metabolic characterization of a G6PC2 inhibitor.

Hawes EM, Rahim M, Haratipour Z, Orun AR, O'Rourke ML, Oeser JK, Kim K, Claxton DP, Blind RD, Young JD, O'Brien RM. Hawes EM, et al. Among authors: o brien rm. Biochimie. 2024 Mar 1;222:109-122. doi: 10.1016/j.biochi.2024.02.012. Online ahead of print. Biochimie. 2024. PMID: 38431189 Free article.

8

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

Wang Y, Oeser JK, Yang C, Sarkar S, Hackl SI, Hasty AH, McGuinness OP, Paradee W, Hutton JC, Powell DR, O'Brien RM. Wang Y, et al. J Biol Chem. 2006 Dec 29;281(52):39982-9. doi: 10.1074/jbc.M605858200. Epub 2006 Oct 5. J Biol Chem. 2006. PMID: 17023421 Free article.

9

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

Ayala JE, Streeper RS, Desgrosellier JS, Durham SK, Suwanichkul A, Svitek CA, Goldman JK, Barr FG, Powell DR, O'Brien RM. Ayala JE, et al. Diabetes. 1999 Sep;48(9):1885-9. doi: 10.2337/diabetes.48.9.1885. Diabetes. 1999. PMID: 10480625

10

Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines.

Bischof LJ, Martin CC, Svitek CA, Stadelmaier BT, Hornbuckle LA, Goldman JK, Oeser JK, Hutton JC, O'Brien RM. Bischof LJ, et al. Diabetes. 2001 Mar;50(3):502-14. doi: 10.2337/diabetes.50.3.502. Diabetes. 2001. PMID: 11246869

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