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DNA-encoded chemical libraries enable the discovery of potent PSMA-ligands with substantially reduced affinity towards the GCPIII anti-target.
Chem Sci. 2024 Apr 2;15(18):6789-6799. doi: 10.1039/d3sc06668a. eCollection 2024 May 8.
Chem Sci. 2024.
PMID: 38725500
Free PMC article.
Discovery of Glutamate Carboxypeptidase III Ligands to Compete the Uptake of [177Lu]Lu-PSMA-617 in Healthy Organs.
Müller M, Lucaroni L, Favalli N, Bassi G, Neri D, Cazzamalli S, Oehler S.
Müller M, et al. Among authors: lucaroni l.
J Med Chem. 2024 May 23;67(10):8247-8260. doi: 10.1021/acs.jmedchem.4c00332. Epub 2024 May 8.
J Med Chem. 2024.
PMID: 38716576
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In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment.
Bocci M, Zana A, Principi L, Lucaroni L, Prati L, Gilardoni E, Neri D, Cazzamalli S, Galbiati A.
Bocci M, et al. Among authors: lucaroni l.
J Control Release. 2024 Mar;367:779-790. doi: 10.1016/j.jconrel.2024.02.014. Epub 2024 Feb 13.
J Control Release. 2024.
PMID: 38346501
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A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition.
Oehler S, Lucaroni L, Migliorini F, Elsayed A, Prati L, Puglioli S, Matasci M, Schira K, Scheuermann J, Yudin D, Jia M, Ban N, Bushnell D, Kornberg R, Cazzamalli S, Neri D, Favalli N, Bassi G.
Oehler S, et al. Among authors: lucaroni l.
Nat Chem. 2023 Oct;15(10):1431-1443. doi: 10.1038/s41557-023-01257-3. Epub 2023 Jul 3.
Nat Chem. 2023.
PMID: 37400597
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Response to: GCP III is not the "off-target" for urea-based PSMA-ligands.
Bassi G, Cazzamalli S, Oehler S, Lucaroni L, Georgiev T, Favalli N, Neri D.
Bassi G, et al. Among authors: lucaroni l.
Eur J Nucl Med Mol Imaging. 2023 Aug;50(10):2947-2949. doi: 10.1007/s00259-023-06302-4. Epub 2023 Jun 21.
Eur J Nucl Med Mol Imaging. 2023.
PMID: 37341746
No abstract available.
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Cross-reactivity to glutamate carboxypeptidase III causes undesired salivary gland and kidney uptake of PSMA-targeted small-molecule radionuclide therapeutics.
Lucaroni L, Georgiev T, Prodi E, Puglioli S, Pellegrino C, Favalli N, Prati L, Manz MG, Cazzamalli S, Neri D, Oehler S, Bassi G.
Lucaroni L, et al.
Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):957-961. doi: 10.1007/s00259-022-05982-8. Epub 2022 Oct 3.
Eur J Nucl Med Mol Imaging. 2023.
PMID: 36184692
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