Dobson RCJ - Search Results

1

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.

Currie MJ, Davies JS, Scalise M, Gulati A, Wright JD, Newton-Vesty MC, Abeysekera GS, Subramanian R, Wahlgren WY, Friemann R, Allison JR, Mace PD, Griffin MDW, Demeler B, Wakatsuki S, Drew D, Indiveri C, Dobson RCJ, North RA. Currie MJ, et al. Among authors: dobson rcj. Elife. 2024 Feb 13;12:RP92307. doi: 10.7554/eLife.92307. Elife. 2024. PMID: 38349818 Free PMC article.

2

Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.

Dobson RC, Griffin MD, Roberts SJ, Gerrard JA. Dobson RC, et al. Biochimie. 2004 Apr-May;86(4-5):311-5. doi: 10.1016/j.biochi.2004.03.008. Biochimie. 2004. PMID: 15194235

3

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.

Dobson RC, Griffin MD, Jameson GB, Gerrard JA. Dobson RC, et al. Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1116-24. doi: 10.1107/S0907444905016318. Epub 2005 Jul 20. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16041077

4

Evolution of quaternary structure in a homotetrameric enzyme.

Griffin MD, Dobson RC, Pearce FG, Antonio L, Whitten AE, Liew CK, Mackay JP, Trewhella J, Jameson GB, Perugini MA, Gerrard JA. Griffin MD, et al. J Mol Biol. 2008 Jul 18;380(4):691-703. doi: 10.1016/j.jmb.2008.05.038. Epub 2008 May 22. J Mol Biol. 2008. PMID: 18556019

5

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.

Burgess BR, Dobson RCJ, Bailey MF, Atkinson SC, Griffin MDW, Jameson GB, Parker MW, Gerrard JA, Perugini MA. Burgess BR, et al. Among authors: dobson rcj. J Biol Chem. 2008 Oct 10;283(41):27598-27603. doi: 10.1074/jbc.M804231200. Epub 2008 Aug 5. J Biol Chem. 2008. PMID: 18684709 Free article.

6

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.

Boughton BA, Griffin MD, O'Donnell PA, Dobson RC, Perugini MA, Gerrard JA, Hutton CA. Boughton BA, et al. Bioorg Med Chem. 2008 Dec 1;16(23):9975-83. doi: 10.1016/j.bmc.2008.10.026. Epub 2008 Oct 17. Bioorg Med Chem. 2008. PMID: 18977662

7

Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?

Griffin MD, Dobson RC, Gerrard JA, Perugini MA. Griffin MD, et al. Arch Biochem Biophys. 2010 Feb 1;494(1):58-63. doi: 10.1016/j.abb.2009.11.014. Epub 2009 Nov 15. Arch Biochem Biophys. 2010. PMID: 19919824

8

Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax.

Voss JE, Scally SW, Taylor NL, Atkinson SC, Griffin MD, Hutton CA, Parker MW, Alderton MR, Gerrard JA, Dobson RC, Dogovski C, Perugini MA. Voss JE, et al. J Biol Chem. 2010 Feb 19;285(8):5188-95. doi: 10.1074/jbc.M109.038166. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948665 Free PMC article.

9

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

Evans G, Schuldt L, Griffin MD, Devenish SR, Grant Pearce F, Perugini MA, Dobson RC, Jameson GB, Weiss MS, Gerrard JA. Evans G, et al. Arch Biochem Biophys. 2011 Aug 15;512(2):154-9. doi: 10.1016/j.abb.2011.05.014. Epub 2011 Jun 7. Arch Biochem Biophys. 2011. PMID: 21672512

10

Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana.

Griffin MD, Billakanti JM, Gerrard JA, Dobson RC, Pearce FG. Griffin MD, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1386-90. doi: 10.1107/S1744309111033276. Epub 2011 Oct 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22102238 Free PMC article.

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