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Page 1
Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Currie MJ, Davies JS, Scalise M, Gulati A, Wright JD, Newton-Vesty MC, Abeysekera GS, Subramanian R, Wahlgren WY, Friemann R, Allison JR, Mace PD, Griffin MDW, Demeler B, Wakatsuki S, Drew D, Indiveri C, Dobson RCJ, North RA. Currie MJ, et al. Among authors: wahlgren wy. Elife. 2024 Feb 13;12:RP92307. doi: 10.7554/eLife.92307. Elife. 2024. PMID: 38349818 Free PMC article.
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.
Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. Wahlgren WY, et al. Nat Commun. 2018 May 1;9(1):1753. doi: 10.1038/s41467-018-04045-7. Nat Commun. 2018. PMID: 29717135 Free PMC article.
The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity.
North RA, Wahlgren WY, Remus DM, Scalise M, Kessans SA, Dunevall E, Claesson E, Soares da Costa TP, Perugini MA, Ramaswamy S, Allison JR, Indiveri C, Friemann R, Dobson RCJ. North RA, et al. Among authors: wahlgren wy. Front Chem. 2018 Jul 4;6:233. doi: 10.3389/fchem.2018.00233. eCollection 2018. Front Chem. 2018. PMID: 30023356 Free PMC article.
Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth.
Bozzola T, Scalise M, Larsson CU, Newton-Vesty MC, Rovegno C, Mitra A, Cramer J, Wahlgren WY, Radhakrishnan Santhakumari P, Johnsson RE, Schwardt O, Ernst B, Friemann R, Dobson RCJ, Indiveri C, Schelin J, Nilsson UJ, Ellervik U. Bozzola T, et al. Among authors: wahlgren wy. ACS Chem Biol. 2022 Jul 15;17(7):1890-1900. doi: 10.1021/acschembio.2c00321. Epub 2022 Jun 8. ACS Chem Biol. 2022. PMID: 35675124 Free PMC article.
"Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes.
North RA, Horne CR, Davies JS, Remus DM, Muscroft-Taylor AC, Goyal P, Wahlgren WY, Ramaswamy S, Friemann R, Dobson RCJ. North RA, et al. Among authors: wahlgren wy. Biophys Rev. 2018 Apr;10(2):219-227. doi: 10.1007/s12551-017-0343-x. Epub 2017 Dec 8. Biophys Rev. 2018. PMID: 29222808 Free PMC article. Review.
Automation aided optimization of cloning, expression and purification of enzymes of the bacterial sialic acid catabolic and sialylation pathways enzymes for structural studies.
Bairy S, Gopalan LN, Setty TG, Srinivasachari S, Manjunath L, Kumar JP, Guntupalli SR, Bose S, Nayak V, Ghosh S, Sathyanarayanan N, Caing-Carlsson R, Wahlgren WY, Friemann R, Ramaswamy S, Neerathilingam M. Bairy S, et al. Among authors: wahlgren wy. Microb Biotechnol. 2018 Mar;11(2):420-428. doi: 10.1111/1751-7915.13041. Epub 2018 Jan 17. Microb Biotechnol. 2018. PMID: 29345069 Free PMC article.
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser.
Claesson E, Wahlgren WY, Takala H, Pandey S, Castillon L, Kuznetsova V, Henry L, Panman M, Carrillo M, Kübel J, Nanekar R, Isaksson L, Nimmrich A, Cellini A, Morozov D, Maj M, Kurttila M, Bosman R, Nango E, Tanaka R, Tanaka T, Fangjia L, Iwata S, Owada S, Moffat K, Groenhof G, Stojković EA, Ihalainen JA, Schmidt M, Westenhoff S. Claesson E, et al. Among authors: wahlgren wy. Elife. 2020 Mar 31;9:e53514. doi: 10.7554/eLife.53514. Elife. 2020. PMID: 32228856 Free PMC article.
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.
Lolli ML, Carnovale IM, Pippione AC, Wahlgren WY, Bonanni D, Marini E, Zonari D, Gallicchio M, Boscaro V, Goyal P, Friemann R, Rolando B, Bagnati R, Adinolfi S, Oliaro-Bosso S, Boschi D. Lolli ML, et al. Among authors: wahlgren wy. ACS Med Chem Lett. 2019 Jan 28;10(4):437-443. doi: 10.1021/acsmedchemlett.8b00484. eCollection 2019 Apr 11. ACS Med Chem Lett. 2019. PMID: 30996776 Free PMC article.
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
Pippione AC, Carnovale IM, Bonanni D, Sini M, Goyal P, Marini E, Pors K, Adinolfi S, Zonari D, Festuccia C, Wahlgren WY, Friemann R, Bagnati R, Boschi D, Oliaro-Bosso S, Lolli ML. Pippione AC, et al. Among authors: wahlgren wy. Eur J Med Chem. 2018 Apr 25;150:930-945. doi: 10.1016/j.ejmech.2018.03.040. Epub 2018 Mar 16. Eur J Med Chem. 2018. PMID: 29602039
27 results