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Structure of the Ebola VP35 interferon inhibitory domain.
Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK. Leung DW, et al. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):411-6. doi: 10.1073/pnas.0807854106. Epub 2009 Jan 2. Proc Natl Acad Sci U S A. 2009. PMID: 19122151 Free PMC article.
Ebolavirus VP35 is a multifunctional virulence factor.
Leung DW, Prins KC, Basler CF, Amarasinghe GK. Leung DW, et al. Virulence. 2010 Nov-Dec;1(6):526-31. doi: 10.4161/viru.1.6.12984. Epub 2010 Nov 1. Virulence. 2010. PMID: 21178490 Free PMC article.
Development of RNA aptamers targeting Ebola virus VP35.
Binning JM, Wang T, Luthra P, Shabman RS, Borek DM, Liu G, Xu W, Leung DW, Basler CF, Amarasinghe GK. Binning JM, et al. Biochemistry. 2013 Nov 26;52(47):8406-19. doi: 10.1021/bi400704d. Epub 2013 Nov 14. Biochemistry. 2013. PMID: 24067086 Free PMC article.
In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK. Brown CS, et al. J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1. J Mol Biol. 2014. PMID: 24495995 Free PMC article.
An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.
Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK. Leung DW, et al. Cell Rep. 2015 Apr 21;11(3):376-89. doi: 10.1016/j.celrep.2015.03.034. Epub 2015 Apr 9. Cell Rep. 2015. PMID: 25865894 Free PMC article.
2,257 results