Cheng H - Search Results

1

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

Poudel YB, He L, Cox M, Zhang Q, Johnson WL, Cong Q, Cheng H, Chowdari NS, Tarby C, Donnell AF, Broekema M, O'Malley DP, Zhang Y, A M Subbaiah M, Kumar BV, Subramani L, Wang B, Li YX, Sivaprakasam P, Critton D, Mulligan D, Sandhu B, Xie C, Ramakrishnan R, Nagar J, Dudhgaonkar S, Oderinde MS, Murtaza A, Schieven GL, Mathur A, Gavai AV, Vite G, Gangwar S. Poudel YB, et al. Among authors: cheng h. ACS Med Chem Lett. 2024 Jan 8;15(2):181-188. doi: 10.1021/acsmedchemlett.3c00455. eCollection 2024 Feb 8. ACS Med Chem Lett. 2024. PMID: 38352830

2

Chemical Modification of Linkers Provides Stable Linker-Payloads for the Generation of Antibody-Drug Conjugates.

Poudel YB, Chowdari NS, Cheng H, Iwuagwu CI, King HD, Kotapati S, Passmore D, Rampulla R, Mathur A, Vite G, Gangwar S. Poudel YB, et al. Among authors: cheng h. ACS Med Chem Lett. 2020 Sep 22;11(11):2190-2194. doi: 10.1021/acsmedchemlett.0c00325. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214828 Free PMC article.

3

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.

Sivaprakasam P, McDonald I, Iwuagwu C, Chowdari NS, Peese KM, Langley DR, Cheng H, Luzung MR, Schmidt MA, Zheng B, Tan Y, Cho P, Rakshit S, Lakshminarasimhan T, Guturi S, Kanagavel K, Kanusu U, Niyogi AG, Sidhar S, Vaidyanathan R, Eastgate MD, Kotapati S, Deshpande M, Pan C, Cardarelli PM, Xie C, Rao C, Holder P, Sarma G, Vite G, Gangwar S. Sivaprakasam P, et al. Among authors: cheng h. ACS Med Chem Lett. 2021 Feb 10;12(3):404-412. doi: 10.1021/acsmedchemlett.0c00578. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738068 Free PMC article.

4

Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues.

Sarkar A, Galasiti Kankanamalage AC, Zhang Q, Cheng H, Sivaprakasam P, Naglich J, Xie C, Gangwar S, Boger DL. Sarkar A, et al. Among authors: cheng h. Med Chem Res. 2021 Jul;30(7):1377-1385. doi: 10.1007/s00044-021-02736-3. Epub 2021 May 18. Med Chem Res. 2021. PMID: 34421287 Free PMC article.

5

Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody-Drug Conjugate.

Cheng H, Cong Q, Dervin D, Stevens A, Vemuri K, Huber M, Juliano J, Cuison S, Sung J, Passmore D, Chong C, Greenbaum M, Kwok E, Jiang J, Pan C, Rao-Naik C, Rangan V, Kempe T, Tatum A, Deshpande S, Cardarelli P, Vite G, Gangwar S. Cheng H, et al. Bioconjug Chem. 2020 Oct 21;31(10):2350-2361. doi: 10.1021/acs.bioconjchem.0c00429. Epub 2020 Sep 11. Bioconjug Chem. 2020. PMID: 32881482

6

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF. Boger DL, et al. Among authors: cheng h. J Med Chem. 2005 Mar 24;48(6):1849-56. doi: 10.1021/jm049614v. J Med Chem. 2005. PMID: 15771430 Free PMC article.

7

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.

Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Leung D, et al. Among authors: cheng h. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1423-8. doi: 10.1016/j.bmcl.2004.12.085. Bioorg Med Chem Lett. 2005. PMID: 15713400

8

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Cheng H, et al. Bioorg Med Chem. 2005 May 16;13(10):3577-85. doi: 10.1016/j.bmc.2004.12.004. Bioorg Med Chem. 2005. PMID: 15848770

9

Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.

Du W, Hardouin C, Cheng H, Hwang I, Boger DL. Du W, et al. Among authors: cheng h. Bioorg Med Chem Lett. 2005 Jan 3;15(1):103-6. doi: 10.1016/j.bmcl.2004.10.025. Bioorg Med Chem Lett. 2005. PMID: 15582420

10

Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.

Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Cheng H, et al. Bioorg Med Chem. 2005 May 16;13(10):3593-9. doi: 10.1016/j.bmc.2004.11.049. Bioorg Med Chem. 2005. PMID: 15848772

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