Svetlov MS - Search Results

1

An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.

Wu KJY, Tresco BIC, Ramkissoon A, Aleksandrova EV, Syroegin EA, See DNY, Liow P, Dittemore GA, Yu M, Testolin G, Mitcheltree MJ, Liu RY, Svetlov MS, Polikanov YS, Myers AG. Wu KJY, et al. Among authors: svetlov ms. Science. 2024 Feb 16;383(6684):721-726. doi: 10.1126/science.adk8013. Epub 2024 Feb 15. Science. 2024. PMID: 38359125

2

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition.

Svetlov MS, Plessa E, Chen CW, Bougas A, Krokidis MG, Dinos GP, Polikanov YS. Svetlov MS, et al. RNA. 2019 May;25(5):600-606. doi: 10.1261/rna.069260.118. Epub 2019 Feb 7. RNA. 2019. PMID: 30733327 Free PMC article.

3

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.

Svetlov MS, Syroegin EA, Aleksandrova EV, Atkinson GC, Gregory ST, Mankin AS, Polikanov YS. Svetlov MS, et al. Nat Chem Biol. 2021 Apr;17(4):412-420. doi: 10.1038/s41589-020-00715-0. Epub 2021 Jan 18. Nat Chem Biol. 2021. PMID: 33462493 Free PMC article.

4

Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.

Chen CW, Leimer N, Syroegin EA, Dunand C, Bulman ZP, Lewis K, Polikanov YS, Svetlov MS. Chen CW, et al. Among authors: svetlov ms. Nat Commun. 2023 Jul 14;14(1):4196. doi: 10.1038/s41467-023-39653-5. Nat Commun. 2023. PMID: 37452045 Free PMC article.

5

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion.

Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: svetlov ms. bioRxiv [Preprint]. 2023 Sep 28:2023.09.27.559749. doi: 10.1101/2023.09.27.559749. bioRxiv. 2023. PMID: 37808676 Free PMC article. Updated. Preprint.

6

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.

Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: svetlov ms. Nat Chem Biol. 2024 Jan 18. doi: 10.1038/s41589-023-01525-w. Online ahead of print. Nat Chem Biol. 2024. PMID: 38238495

7

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.

Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS. Almutairi MM, et al. Among authors: svetlov ms. Nucleic Acids Res. 2017 Sep 19;45(16):9573-9582. doi: 10.1093/nar/gkx673. Nucleic Acids Res. 2017. PMID: 28934499 Free PMC article.

8

A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria.

Svetlov MS, Cohen S, Alsuhebany N, Vázquez-Laslop N, Mankin AS. Svetlov MS, et al. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):1971-1975. doi: 10.1073/pnas.1918948117. Epub 2020 Jan 13. Proc Natl Acad Sci U S A. 2020. PMID: 31932436 Free PMC article.

9

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics.

Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN. Beckert B, et al. Among authors: svetlov ms. Nat Commun. 2021 Jul 22;12(1):4466. doi: 10.1038/s41467-021-24674-9. Nat Commun. 2021. PMID: 34294725 Free PMC article.

10

Ribosome-Associated Quality Control in Bacteria.

Svetlov MS. Svetlov MS. Biochemistry (Mosc). 2021 Aug;86(8):942-951. doi: 10.1134/S0006297921080058. Biochemistry (Mosc). 2021. PMID: 34488571 Free article. Review.

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