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Page 1
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Wu KJY, Tresco BIC, Ramkissoon A, Aleksandrova EV, Syroegin EA, See DNY, Liow P, Dittemore GA, Yu M, Testolin G, Mitcheltree MJ, Liu RY, Svetlov MS, Polikanov YS, Myers AG. Wu KJY, et al. Among authors: tresco bic. Science. 2024 Feb 16;383(6684):721-726. doi: 10.1126/science.adk8013. Epub 2024 Feb 15. Science. 2024. PMID: 38359125
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.
Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: tresco bic. Nat Chem Biol. 2024 Jan 18. doi: 10.1038/s41589-023-01525-w. Online ahead of print. Nat Chem Biol. 2024. PMID: 38238495
Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, Lim KS, Poirier J, Capece J, Bonazzi S, Gampe CM, Smith NJ, Bradner JE, Coley CW, Clemons PA, Melillo B, Hon CS, Ottl J, Dumelin CE, Schaefer JV, Faust AME, Berst F, Schreiber SL, Zécri FJ, Briner K. Hudson L, et al. Among authors: tresco bic. Nat Commun. 2023 Nov 21;14(1):7589. doi: 10.1038/s41467-023-43518-2. Nat Commun. 2023. PMID: 37989745 Free PMC article. No abstract available.
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion.
Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: tresco bic. bioRxiv [Preprint]. 2023 Sep 28:2023.09.27.559749. doi: 10.1101/2023.09.27.559749. bioRxiv. 2023. PMID: 37808676 Free PMC article. Updated. Preprint.
Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, Lim KS, Poirier J, Capece J, Bonazzi S, Gampe CM, Smith NJ, Bradner JE, Coley CW, Clemons PA, Melillo B, Hon CS, Ottl J, Dumelin CE, Schaefer JV, Faust AME, Berst F, Schreiber SL, Zécri FJ, Briner K. Hudson L, et al. Among authors: tresco bic. Nat Commun. 2023 Aug 15;14(1):4930. doi: 10.1038/s41467-023-40575-5. Nat Commun. 2023. PMID: 37582753 Free PMC article.
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.
Obana N, Takada H, Crowe-McAuliffe C, Iwamoto M, Egorov AA, Wu KJY, Chiba S, Murina V, Paternoga H, Tresco BIC, Nomura N, Myers AG, Atkinson GC, Wilson DN, Hauryliuk V. Obana N, et al. Among authors: tresco bic. Nucleic Acids Res. 2023 May 22;51(9):4536-4554. doi: 10.1093/nar/gkad193. Nucleic Acids Res. 2023. PMID: 36951104 Free PMC article.
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp.
Takada H, Mandell ZF, Yakhnin H, Glazyrina A, Chiba S, Kurata T, Wu KJY, Tresco BIC, Myers AG, Aktinson GC, Babitzke P, Hauryliuk V. Takada H, et al. Among authors: tresco bic. Nucleic Acids Res. 2022 Jun 24;50(11):6174-6189. doi: 10.1093/nar/gkac497. Nucleic Acids Res. 2022. PMID: 35699226 Free PMC article.