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Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
Huston A, Leleu X, Jia X, Moreau AS, Ngo HT, Runnels J, Anderson J, Alsayed Y, Roccaro A, Vallet S, Hatjiharissi E, Tai YT, Sportelli P, Munshi N, Richardson P, Hideshima T, Roodman DG, Anderson KC, Ghobrial IM. Huston A, et al. Clin Cancer Res. 2008 Feb 1;14(3):865-74. doi: 10.1158/1078-0432.CCR-07-1299. Clin Cancer Res. 2008. PMID: 18245550
Targeting NF-kappaB in Waldenstrom macroglobulinemia.
Leleu X, Eeckhoute J, Jia X, Roccaro AM, Moreau AS, Farag M, Sacco A, Ngo HT, Runnels J, Melhem MR, Burwick N, Azab A, Azab F, Hunter Z, Hatjiharissi E, Carrasco DR, Treon SP, Witzig TE, Hideshima T, Brown M, Anderson KC, Ghobrial IM. Leleu X, et al. Among authors: roccaro am. Blood. 2008 May 15;111(10):5068-77. doi: 10.1182/blood-2007-09-115170. Epub 2008 Mar 11. Blood. 2008. PMID: 18334673 Free PMC article.
Targeted therapies in Waldenström macroglobulinemia.
Burwick N, Roccaro AM, Leleu X, Ghobrial IM. Burwick N, et al. Among authors: roccaro am. Curr Opin Investig Drugs. 2008 Jun;9(6):631-7. Curr Opin Investig Drugs. 2008. PMID: 18516762 Review.
The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia.
Moreau AS, Jia X, Patterson CJ, Roccaro AM, Xu L, Sacco A, O'Connor K, Soumerai J, Ngo HT, Hatjiharissi E, Hunter ZR, Ciccarelli B, Manning R, Ghobrial IM, Leleu X, Treon SP. Moreau AS, et al. Among authors: roccaro am. Br J Haematol. 2008 Sep;142(5):775-85. doi: 10.1111/j.1365-2141.2008.07257.x. Epub 2008 Jun 3. Br J Haematol. 2008. PMID: 18537966 Free article.
Waldenstrom macroglobulinemia.
Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J, Hatjiharissi E, Burwik N, Ghobrial IM. Leleu X, et al. Among authors: roccaro am. Cancer Lett. 2008 Oct 18;270(1):95-107. doi: 10.1016/j.canlet.2008.04.040. Epub 2008 Jun 13. Cancer Lett. 2008. PMID: 18555588 Free PMC article.
Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia.
Leleu X, Xu L, Jia X, Sacco A, Farag M, Hunter ZR, Moreau AS, Ngo HT, Hatjiharissi E, Ho AW, Santos DD, Adamia S, O'Connor K, Ciccarelli B, Soumerai J, Manning RJ, Patterson CJ, Roccaro AM, Ghobrial IM, Treon SP. Leleu X, et al. Among authors: roccaro am. Blood. 2009 Jan 15;113(3):626-34. doi: 10.1182/blood-2007-10-116848. Epub 2008 Nov 3. Blood. 2009. PMID: 18981296 Free article.
181 results