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Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials.
Sang H, Cao Z, Du J, Nguyen TN, Saver JL, Mao A, Nogueira RG, Tao Z, Zhou S, Han Q, Sun D, Lei B, Liu S, Zeng G, Yin C, Xie D, Luo W, Jin Z, Qiu Z; DEVT and RESCUE BT Trial Investigators. Sang H, et al. Among authors: mao a. Stroke. 2024 Apr;55(4):856-865. doi: 10.1161/STROKEAHA.123.044562. Epub 2024 Feb 16. Stroke. 2024. PMID: 38362756
Values of Baseline Posterior Circulation Acute Stroke Prognosis Early Computed Tomography Score for Treatment Decision of Acute Basilar Artery Occlusion.
Sang H, Li F, Yuan J, Liu S, Luo W, Wen C, Zhu Q, Chen W, Lin M, Qi L, Zhong Y, Wang Z, Ling W, Shi Z, Chen H, Liu W, Liu Z, Yao X, Xiong F, Zeng G, Hu X, Dong H, Mao A, Yang G, Huang J, Chen L, Gong Z, Tao J, Liu H, Wu D, Qiu Z, Yang Q, Zi W, Li F. Sang H, et al. Among authors: mao a. Stroke. 2021 Mar;52(3):811-820. doi: 10.1161/STROKEAHA.120.031371. Epub 2021 Feb 11. Stroke. 2021. PMID: 33567874
Association between intravenous tirofiban and intracranial hemorrhage in acute large vessel occlusion stroke: insight from the RESCUE BT randomized placebo-controlled trial.
Sang H, Huang J, Jiang B, Guo Q, Nguyen TN, Abdalkader M, Han Q, Zhou S, Tao Z, Mao A, Yan Z, Du J, Jin Y, Huang C, Liu T, Zhao W, Gu G, Wang L, Liu S, Luo S, Pu J, Hu J, Yang J, Li F, Zi W, Hu X, Qiu Z. Sang H, et al. Among authors: mao a. J Neurol. 2023 Apr;270(4):2246-2255. doi: 10.1007/s00415-023-11579-4. Epub 2023 Jan 25. J Neurol. 2023. PMID: 36697890 Clinical Trial.
Tyrosinase deficiency impairs social novelty preference in mice.
Aizawa S, Yamamuro Y. Aizawa S, et al. Neuroreport. 2024 May 30. doi: 10.1097/WNR.0000000000002055. Online ahead of print. Neuroreport. 2024. PMID: 38829918
We also found that the hippocampal expression of genes involved in catecholamine metabolism, such as monoamine oxidase A and catechol-O-methyltransferase, were significantly decreased in tyrosinase-deficient B10-c mice. ...
We also found that the hippocampal expression of genes involved in catecholamine metabolism, such as monoamine oxidase A and c …
Targeting Biometals in Alzheimer's Disease with Metal Chelating Agents Including Coumarin Derivatives.
Gucký A, Hamuľaková S. Gucký A, et al. CNS Drugs. 2024 Jun 3. doi: 10.1007/s40263-024-01093-0. Online ahead of print. CNS Drugs. 2024. PMID: 38829443 Review.
Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit cholinesterases (ChEs) and monoamine oxidase B (MAO-B) while also possessing antioxidant, anti-inflammatory, and numerous other …
Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit ch …
Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from Vitis vinifera: a case study of Alzheimer's disease (AD).
Sofela SO, Ibrahim A, Ogbodo UC, Bodun DS, Nwankwo DO, Mafimisebi M, Abdulrasheed B, Balogun T, Opeyemi I. Sofela SO, et al. In Silico Pharmacol. 2024 May 31;12(1):49. doi: 10.1007/s40203-024-00214-3. eCollection 2024. In Silico Pharmacol. 2024. PMID: 38828442
At the same time, the currently available anti-cholinesterase (AChE) and monoamine oxidase-B (MAO-B) for the treatment of AD can only improve the clinical symptoms while the recently approved immunotherapy agent "remains questionable. ...
At the same time, the currently available anti-cholinesterase (AChE) and monoamine oxidase-B (MAO-B) for the treatment of AD c …
Pharmacological and behavioural effects of tryptamines present in psilocybin-containing mushrooms.
Rakoczy RJ, Runge GN, Sen AK, Sandoval O, Wells HG, Nguyen Q, Roberts BR, Sciortino JH, Gibbons WJ Jr, Friedberg LM, Jones JA, McMurray MS. Rakoczy RJ, et al. Br J Pharmacol. 2024 Jun 2. doi: 10.1111/bph.16466. Online ahead of print. Br J Pharmacol. 2024. PMID: 38825326
KEY RESULTS: In vitro enzyme kinetics assays found that all compounds had nearly identical rates of dephosphorylation via alkaline phosphatase and metabolism by monoamine oxidase. Further, we found that only the dephosphorylated products of baeocystin and norbaeocys …
KEY RESULTS: In vitro enzyme kinetics assays found that all compounds had nearly identical rates of dephosphorylation via alkaline phosphata …
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