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Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase.
Amore BM, MacDougall DE, Hanselman JC, Emery MG. Amore BM, et al. Among authors: macdougall de. Clin Pharmacol Drug Dev. 2023 Oct;12(10):1022-1035. doi: 10.1002/cpdd.1297. Epub 2023 Jul 21. Clin Pharmacol Drug Dev. 2023. PMID: 37477389 Clinical Trial.
Complementary low-density lipoprotein-cholesterol lowering and pharmacokinetics of adding bempedoic acid (ETC-1002) to high-dose atorvastatin background therapy in hypercholesterolemic patients: A randomized placebo-controlled trial.
Lalwani ND, Hanselman JC, MacDougall DE, Sterling LR, Cramer CT. Lalwani ND, et al. Among authors: macdougall de. J Clin Lipidol. 2019 Jul-Aug;13(4):568-579. doi: 10.1016/j.jacl.2019.05.003. Epub 2019 May 13. J Clin Lipidol. 2019. PMID: 31202641 Clinical Trial.
Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance.
Thompson PD, MacDougall DE, Newton RS, Margulies JR, Hanselman JC, Orloff DG, McKenney JM, Ballantyne CM. Thompson PD, et al. Among authors: macdougall de. J Clin Lipidol. 2016 May-Jun;10(3):556-67. doi: 10.1016/j.jacl.2015.12.025. Epub 2016 Jan 6. J Clin Lipidol. 2016. PMID: 27206943 Free article. Clinical Trial.
Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance.
Thompson PD, Rubino J, Janik MJ, MacDougall DE, McBride SJ, Margulies JR, Newton RS. Thompson PD, et al. Among authors: macdougall de. J Clin Lipidol. 2015 May-Jun;9(3):295-304. doi: 10.1016/j.jacl.2015.03.003. Epub 2015 Mar 19. J Clin Lipidol. 2015. PMID: 26073387 Free article. Clinical Trial.
Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus.
Gutierrez MJ, Rosenberg NL, Macdougall DE, Hanselman JC, Margulies JR, Strange P, Milad MA, McBride SJ, Newton RS. Gutierrez MJ, et al. Among authors: macdougall de. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):676-83. doi: 10.1161/ATVBAHA.113.302677. Epub 2014 Jan 2. Arterioscler Thromb Vasc Biol. 2014. PMID: 24385236 Clinical Trial.
19 results