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Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation.
Venkatasubramanian M, Schwartz L, Ramachandra N, Bennett J, Subramanian KR, Chen X, Gordon-Mitchell S, Fromowitz A, Pradhan K, Shechter D, Sahu S, Heiser D, Scherle P, Chetal K, Kulkarni A, Myers KC, Weirauch MT, Grimes HL, Starczynowski DT, Verma A, Salomonis N. Venkatasubramanian M, et al. Among authors: chen x. bioRxiv [Preprint]. 2024 Feb 8:2024.02.04.578798. doi: 10.1101/2024.02.04.578798. bioRxiv. 2024. PMID: 38370617 Free PMC article. Preprint.
Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.
Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, Komurov K, Weirauch MT, Cancelas JA, Maciejewski JP, Starczynowski DT. Fang J, et al. Among authors: chen x. Cell Rep. 2014 Sep 11;8(5):1328-38. doi: 10.1016/j.celrep.2014.07.062. Epub 2014 Sep 4. Cell Rep. 2014. PMID: 25199827 Free PMC article.
Deciphering cis-regulatory grammar with deep learning.
Miraldi ER, Chen X, Weirauch MT. Miraldi ER, et al. Among authors: chen x. Nat Genet. 2021 Mar;53(3):266-268. doi: 10.1038/s41588-021-00814-1. Nat Genet. 2021. PMID: 33686263 No abstract available.
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.
Nigrovic PA, Wang Q, Kim T, Martinez-Bonet M, Aguiar VRC, Sim S, Cui J, Sparks JA, Chen X, Todd M, Wauford B, Marion MC, Langefeld CD, Weirauch MT, Gutierrez-Arcelus M. Nigrovic PA, et al. Among authors: chen x. bioRxiv [Preprint]. 2024 Apr 12:2023.08.16.553538. doi: 10.1101/2023.08.16.553538. bioRxiv. 2024. PMID: 37645953 Free PMC article. Preprint.
Accessible chromatin maps of inflammatory bowel disease intestine nominate cell-type mediators of genetic disease risk.
Wayman JA, Yang Z, Angerman E, Bonkowski E, Jurickova I, Chen X, Bejjani AT, Parks L, Parameswaran S, Miethke AG, VanDussen KL, Dhaliwal J, Weirauch MT, Kottyan LC, Denson LA, Miraldi ER. Wayman JA, et al. Among authors: chen x. bioRxiv [Preprint]. 2024 Feb 13:2024.02.09.579678. doi: 10.1101/2024.02.09.579678. bioRxiv. 2024. PMID: 38405748 Free PMC article. Preprint.
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development.
Kim T, Martínez-Bonet M, Wang Q, Hackert N, Sparks JA, Baglaenko Y, Koh B, Darbousset R, Laza-Briviesca R, Chen X, Aguiar VRC, Chiu DJ, Westra HJ, Gutierrez-Arcelus M, Weirauch MT, Raychaudhuri S, Rao DA, Nigrovic PA. Kim T, et al. Among authors: chen x. Nat Commun. 2024 Mar 9;15(1):2150. doi: 10.1038/s41467-024-46457-8. Nat Commun. 2024. PMID: 38459032 Free PMC article.
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