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Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation.
Venkatasubramanian M, Schwartz L, Ramachandra N, Bennett J, Subramanian KR, Chen X, Gordon-Mitchell S, Fromowitz A, Pradhan K, Shechter D, Sahu S, Heiser D, Scherle P, Chetal K, Kulkarni A, Myers KC, Weirauch MT, Grimes HL, Starczynowski DT, Verma A, Salomonis N. Venkatasubramanian M, et al. Among authors: kulkarni a. bioRxiv [Preprint]. 2024 Feb 8:2024.02.04.578798. doi: 10.1101/2024.02.04.578798. bioRxiv. 2024. PMID: 38370617 Free PMC article. Preprint.
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.
Smith MA, Choudhary GS, Pellagatti A, Choi K, Bolanos LC, Bhagat TD, Gordon-Mitchell S, Von Ahrens D, Pradhan K, Steeples V, Kim S, Steidl U, Walter M, Fraser IDC, Kulkarni A, Salomonis N, Komurov K, Boultwood J, Verma A, Starczynowski DT. Smith MA, et al. Among authors: kulkarni a. Nat Cell Biol. 2019 May;21(5):640-650. doi: 10.1038/s41556-019-0314-5. Epub 2019 Apr 22. Nat Cell Biol. 2019. PMID: 31011167 Free PMC article.
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Itskovich SS, Gurunathan A, Clark J, Burwinkel M, Wunderlich M, Berger MR, Kulkarni A, Chetal K, Venkatasubramanian M, Salomonis N, Kumar AR, Lee LH. Itskovich SS, et al. Among authors: kulkarni a. Nat Commun. 2020 May 12;11(1):2369. doi: 10.1038/s41467-020-15733-8. Nat Commun. 2020. PMID: 32398749 Free PMC article.
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies.
Fenix AM, Miyaoka Y, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, Mayerl SJ, Nguyen TD, Russell CR, Lizarraga PP, Truong A, So PL, Kulkarni A, Chetal K, Sathe S, Sniadecki NJ, Yeo GW, Murry CE, Conklin BR, Salomonis N. Fenix AM, et al. Among authors: kulkarni a. Nat Commun. 2021 Nov 3;12(1):6324. doi: 10.1038/s41467-021-26623-y. Nat Commun. 2021. PMID: 34732726 Free PMC article.
Look-alike, sound-alike (LASA) drugs in India.
Neelakantan M, Sharma P, Kulkarni A. Neelakantan M, et al. Among authors: kulkarni a. Lancet Reg Health Southeast Asia. 2024 May 16;26:100425. doi: 10.1016/j.lansea.2024.100425. eCollection 2024 Jul. Lancet Reg Health Southeast Asia. 2024. PMID: 38798984 Free PMC article. Review.
Downstaging with Atezolizumab-Bevacizumab: A Case Series.
Kulkarni AV, P K, Menon B, Sekaran A, Rambhatl A, Iyengar S, Alla M, Venishetty S, Ramachandra SK, V PG, Sharma M, Rao PN, Reddy DN, Singal AG. Kulkarni AV, et al. J Liver Cancer. 2024 May 27. doi: 10.17998/jlc.2024.05.12. Online ahead of print. J Liver Cancer. 2024. PMID: 38797993 Free article.
Scurvy in an Adolescent: A Case Report.
Du T, Kulkarni A. Du T, et al. Among authors: kulkarni a. Cureus. 2024 Apr 22;16(4):e58782. doi: 10.7759/cureus.58782. eCollection 2024 Apr. Cureus. 2024. PMID: 38784361 Free PMC article.
Myocardial injury after noncardiac surgery.
Kulkarni A, Marcucci M, Nguyen JMV. Kulkarni A, et al. CMAJ. 2024 May 20;196(19):E661. doi: 10.1503/cmaj.231355. CMAJ. 2024. PMID: 38772601 Free PMC article. Review. No abstract available.
3,054 results