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A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
Haage V, Tuddenham JF, Comandante-Lou N, Bautista A, Monzel A, Chiu R, Fujita M, Garcia FG, Bhattarai P, Patel R, Buonfiglioli A, Idiarte J, Herman M, Rinderspacher A, Mela A, Zhao W, Argenziano MG, Furnari JL, Banu MA, Landry DW, Bruce JN, Canoll P, Zhang Y, Nuriel T, Kizil C, Sproul AA, de Witte LD, Sims PA, Menon V, Picard M, De Jager PL. Haage V, et al. Among authors: argenziano mg. bioRxiv [Preprint]. 2024 Feb 6:2024.02.06.579103. doi: 10.1101/2024.02.06.579103. bioRxiv. 2024. PMID: 38370689 Free PMC article. Preprint.
Thoracic low grade glial neoplasm with concurrent H3 K27M and PTPN11 mutations.
Argenziano MG, Furnari JL, Miller ML, Sun Y, Banu MA, Neira JA, Snuderl M, Bruce JN, Welch M, McCormick P, Canoll P. Argenziano MG, et al. Acta Neuropathol Commun. 2022 Apr 28;10(1):64. doi: 10.1186/s40478-022-01340-9. Acta Neuropathol Commun. 2022. PMID: 35484611 Free PMC article.
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan A, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania V, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz A, Lignelli A, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D'Amico RS, Grinband J, Canoll P, Bruce JN. Spinazzi EF, et al. Among authors: argenziano mg. Lancet Oncol. 2022 Nov;23(11):1409-1418. doi: 10.1016/S1470-2045(22)00599-X. Epub 2022 Oct 13. Lancet Oncol. 2022. PMID: 36243020 Free PMC article. Clinical Trial.
Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities.
Kenchappa RS, Liu Y, Argenziano MG, Banu MA, Mladek AC, West R, Luu A, Quiñones-Hinojosa A, Hambardzumyan D, Justilien V, Leitges M, Sarkaria JN, Sims PA, Canoll P, Murray NR, Fields AP, Rosenfeld SS. Kenchappa RS, et al. Among authors: argenziano mg. Cell Rep. 2021 Nov 23;37(8):110054. doi: 10.1016/j.celrep.2021.110054. Cell Rep. 2021. PMID: 34818553 Free PMC article.
Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma.
Kenchappa RS, Dovas A, Argenziano MG, Meyer CT, Stopfer LE, Banu MA, Pereira B, Griffith J, Mohammad A, Talele S, Haddock A, Zarco N, Elmquist W, White F, Quaranta V, Sims P, Canoll P, Rosenfeld SS. Kenchappa RS, et al. Among authors: argenziano mg. Cell Rep. 2022 Jun 21;39(12):110991. doi: 10.1016/j.celrep.2022.110991. Cell Rep. 2022. PMID: 35732128 Free PMC article.
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