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Page 1
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
Haage V, Tuddenham JF, Comandante-Lou N, Bautista A, Monzel A, Chiu R, Fujita M, Garcia FG, Bhattarai P, Patel R, Buonfiglioli A, Idiarte J, Herman M, Rinderspacher A, Mela A, Zhao W, Argenziano MG, Furnari JL, Banu MA, Landry DW, Bruce JN, Canoll P, Zhang Y, Nuriel T, Kizil C, Sproul AA, de Witte LD, Sims PA, Menon V, Picard M, De Jager PL. Haage V, et al. Among authors: sproul aa. bioRxiv [Preprint]. 2024 Feb 6:2024.02.06.579103. doi: 10.1101/2024.02.06.579103. bioRxiv. 2024. PMID: 38370689 Free PMC article. Preprint.
Genetic control of manno(fructo)kinase activity in Escherichia coli.
Sproul AA, Lambourne LT, Jean-Jacques D J, Kornberg HL. Sproul AA, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15257-9. doi: 10.1073/pnas.211569798. Epub 2001 Dec 11. Proc Natl Acad Sci U S A. 2001. PMID: 11742072 Free PMC article.
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Peris L, Parato J, Qu X, Soleilhac JM, Lanté F, Kumar A, Pero ME, Martínez-Hernández J, Corrao C, Falivelli G, Payet F, Gory-Fauré S, Bosc C, Blanca Ramirez M, Sproul A, Brocard J, Di Cara B, Delagrange P, Buisson A, Goldberg Y, Moutin MJ, Bartolini F, Andrieux A. Peris L, et al. Brain. 2022 Jul 29;145(7):2486-2506. doi: 10.1093/brain/awab436. Brain. 2022. PMID: 35148384 Free PMC article.
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease.
Bartosch AMW, Youth EHH, Hansen S, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. Bartosch AMW, et al. Among authors: sproul aa. bioRxiv [Preprint]. 2023 Mar 21:2023.03.21.533654. doi: 10.1101/2023.03.21.533654. bioRxiv. 2023. PMID: 36993746 Free PMC article. Updated. Preprint.
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.
Al-Dalahmah O, Lam M, McInvale JJ, Qu W, Nguyen T, Mun JY, Kwon S, Ifediora N, Mahajan A, Humala N, Winters T, Angeles E, Jakubiak KA, Kühn R, Kim YA, De Rosa MC, Doege CA, Paryani F, Flowers X, Dovas A, Mela A, Lu H, DeTure MA, Vonsattel JP, Wszolek ZK, Dickson DW, Kuhlmann T, Zaehres H, Schöler HR, Sproul AA, Siegelin MD, De Jager PL, Goldman JE, Menon V, Canoll P, Hargus G. Al-Dalahmah O, et al. Among authors: sproul aa. Cell Stem Cell. 2024 May 2;31(5):676-693.e10. doi: 10.1016/j.stem.2024.03.013. Epub 2024 Apr 15. Cell Stem Cell. 2024. PMID: 38626772 Free article.
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Kim YA, Siddiqui T, Blaze J, Cosacak MI, Winters T, Kumar A, Tein E, Sproul AA, Teich AF, Bartolini F, Akbarian S, Kizil C, Hargus G, Santa-Maria I. Kim YA, et al. Among authors: sproul aa. Acta Neuropathol. 2023 Jan;145(1):29-48. doi: 10.1007/s00401-022-02511-7. Epub 2022 Nov 10. Acta Neuropathol. 2023. PMID: 36357715 Free PMC article.
ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease.
Bartosch AMW, Youth EHH, Hansen S, Wu Y, Buchanan HM, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. Bartosch AMW, et al. Among authors: sproul aa. J Neurosci. 2024 Jan 17;44(3):e2324222023. doi: 10.1523/JNEUROSCI.2324-22.2023. J Neurosci. 2024. PMID: 38050142
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics.
Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, Shelanski ML, Bouaziz S, Karin M, El Amri C, Jacotot ED. Bosc E, et al. Among authors: sproul aa. Cell Death Dis. 2022 Nov 15;13(11):959. doi: 10.1038/s41419-022-05396-2. Cell Death Dis. 2022. PMID: 36379916 Free PMC article.
22 results